PMID: 25743793Mar 7, 2015Paper

Serum levels of MMP9 and MMP2 in patients with oral squamous cell carcinoma

Asian Pacific Journal of Cancer Prevention : APJCP
Alireza LotfiLale Saniee

Abstract

Squamous cell carcinoma (SCC) is the most common cancer in the oral area. Matrix metalloproteinases (MMPs) and especially MMP-2 and MMP-9 are increased in malignancy and lymph node involvement in oral SCCs. We aimed to evaluate the serum levels of MMP-2 and MMP-9 in patients with oral SCC compared to normal subjects and their relation with clinicopathological findings. In this case control study, 20 patients with oral SCC and 20 healthy subjects were included and serum levels of MMP-2 and MMP-9 were compared between groups. Also, the correlation between these markers with clinicopathological findings including grade (T) and node (N) were evaluated. Patients with oral SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p<0.001) compared to healthy subjects. With increase in grade T, MMP-2 was significantly increased (p=0.001), but in the MMP-9 case this was not significant (p=0.27). The levels of MMP-2 (p=0.002) and MMP-9 (p=0.01) in cases with lymph node involvement and that of MMP-2 in subjects with smoking history (p=0.001) were significantly high. There was significantly positive correlation between MMP-2 with grade T tumor (r=0.598, p=0.005), lymph node involvement (r=0.737, p<0.001) and smoking (r=0.674,...Continue Reading

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Citations

Jan 29, 2016·Biosensors & Bioelectronics·Yung-Chieh ChanMichael Hsiao
Oct 11, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Archana Venugopal, T N Uma Maheswari
Oct 14, 2018·Oral Diseases·Meri SieviläinenAlhadi Almangush
Oct 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Alireza LotfiAtena Tavassoli
Dec 2, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tasha BarrIlhem Messaoudi
Sep 19, 2020·Bioscience, Biotechnology, and Biochemistry·Mingxiang CaoXubei Ding
Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Narendra Prakash RaiShabil Mohamed Mustafa
Oct 14, 2020·Journal of Receptor and Signal Transduction Research·Luping LiuLi Cui
Oct 14, 2020·Biochemistry. Biokhimii︠a︡·O L Gorbunova, S V Shirshev

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