Serum levels of N-terminal pro-B-type natriuretic peptide are associated with allograft function in recipients of renal transplants.

Wiener klinische Wochenschrift
Gerd BodlajJörg Berg

Abstract

B-type natriuretic peptide (BNP) plays a key role in the regulation of volume homeostasis, and elevated blood levels of BNP are associated with end-stage renal disease. Renal transplantation leads to a decrease of elevated BNP levels with established graft function. Assessment of N-terminal pro-BNP (NT-proBNP) is established as reflecting volume homeostasis, and we therefore studied the relationship between NT-proBNP and allograft function in a prospective study. NT-proBNP was assessed in 76 patients with end-stage renal disease undergoing renal transplantation. Patients were grouped according to immediate or delayed graft function. The degree of allograft function was assessed from the estimated glomerular filtration rate according to the MDRD formula. In patients with immediate graft function (n = 48), median NT-proBNP decreased immediately after transplantation; in patients with delayed function (n = 28), median NT-proBNP first increased and then decreased as function improved. Patients with early acute rejection showed significantly higher NT-proBNP levels prior to transplantation than patients without rejection. NT-proBNP levels measured 2 or 3 weeks post-transplant were significantly correlated with the estimated glomerul...Continue Reading

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Citations

Feb 17, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Balaji KrishnanDavid G Benditt
Apr 12, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Matthew A RobertsFrancesco L Ierino
Nov 19, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Gates ColbertS Susan Hedayati
Apr 29, 2014·Transplantation·Winnie ChanRichard Borrows

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