Abstract
Osteopontin (OPN) is a multifunctional glycophosphoprotein that was detected in many carcinomas, and it may have a prognostic role. The aim of this study was to determine osteopontin serum levels in patients with oral squamous cell carcinoma (OSCC) and investigated its correlation with clinicopathological features of tumor. Using an ELISA kit, we assessed and compared the circulating levels of OPN in blood serum of 45 oral squamous cell carcinoma patients with 45 healthy control samples. The serum osteopontin level in patients with OSCC was significantly higher (145.8 ± 14.6 ng/ml, n = 45) compared with the healthy controls (53.9 ± 9.6 ng/ml, n = 45, p < 0.001). Mean serum osteopontin level was significantly higher in patients with nodal metastasis (p = 0.03) and higher stage (p = 0.02). Findings of the present study suggest that OPN may have a potential role in pathogenesis of OSCC and it may be used as a tool for monitoring tumor progression.
References
Apr 1, 1979·Cell·D R SengerR O Hynes
May 16, 1998·International Journal of Cancer. Journal International Du Cancer·T UeE Tahara
Feb 5, 2002·Biochimica Et Biophysica Acta·G F Weber
Aug 2, 2003·Cancer Letters·Michihiro HiramaYoshinosuke Fukuchi
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Domenico CoppolaTimothy J Yeatman
May 12, 2004·Cancer Biology & Therapy·N Tjarda Van HeekMichael Goggins
Oct 27, 2004·The Journal of Surgical Research·Philip Y Wai, Paul C Kuo
Jun 1, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T S WongA P-W Yuen
Jun 14, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ph Meijnen, E J Th Rutgers
Dec 22, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H MatsuzakiM Shimono
Jan 27, 2007·Auris, Nasus, Larynx·Mayumi EtoMasashi Suzuki
May 22, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yoon Soo ChangSe Kyu Kim
Jan 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hisao AsamuraUNKNOWN Japanese Joint Committee of Lung Cancer Registry
Mar 9, 2010·Cancer Letters·Hao LiuLin Yuan
Mar 12, 2010·Oral Oncology·Yu-Wei ChiuShou-Yen Kao
Nov 6, 2012·Clinical Lung Cancer·Masaru TakenakaFumihiro Tanaka
May 29, 2013·Annals of Diagnostic Pathology·Samapika RoutrayMohit Kheur
Citations
Dec 17, 2014·FEBS Letters·Takuya NakamuraYukio Ando
Oct 17, 2015·Cancer Medicine·Katia I Camacho-CáceresClara E Isaza
Jul 30, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Joanne E Murphy-Ullrich, E Helene Sage
Dec 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kun SongXue Qiu
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lucas Novaes TeixeiraPaulo Tambasco de Oliveira
May 10, 2017·Journal of Oral and Maxillofacial Pathology : JOMFP·Thara AravindU G Unnikrishnan
Nov 15, 2020·Oral Diseases·Erison Santana Dos SantosAdriana Franco Paes Leme