Serum levels of osteoprotegerin and osteoprotegerin polymorphisms in Gaucher disease

British Journal of Haematology
Itai MagalDeborah Elstein

Abstract

Bone involvement in Gaucher disease causes disability and reduced quality of life; loss of function and pain are important indications for enzyme replacement therapy. The purpose of this study was to ascertain whether osteoprotegerin (OPG), which decreases osteoclast activity, is indicative of incipient bone involvement by comparing OPG serum levels to Gaucher disease severity (SSI) and bone mineral density (BMD), and to correlate bone and disease markers to OPG polymorphisms: OPG1-2(A163G), OPG3-4(T129C) and OPG5-6(C1217T). Of 554 patients, 173 Ashkenazi Jewish patients with non-neuronopathic Gaucher disease were enrolled and 32 healthy Ashkenazi Jews served as controls. Serum OPG levels were detected by enzyme-linked immunosorbent assay and BMD was obtained by dual X-ray absorptiometry. OPG polymorphisms were determined in 63 randomly chosen patients. Serum OPG values for patients were not greater than in controls, but showed a statistically significant trend to increase with age (P = 0.057). No correlation existed between OPG levels and BMD or with genotype or other disease markers. A significant correlation was noted between OPG5-6 genotype and SSI. A significant difference was found between the allele distributions of each...Continue Reading

References

Mar 31, 1988·The New England Journal of Medicine·L G Raisz
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R PacificiW A Peck
Jan 1, 1997·QJM : Monthly Journal of the Association of Physicians·M J AllenT M Cox
Mar 28, 1998·Blood Cells, Molecules & Diseases·M LichtensteinM Horowitz
Mar 14, 1998·Baillière's Clinical Haematology·D ElsteinH J Mankin
Jan 23, 1999·The American Journal of Pathology·K D MerkelS L Teitelbaum
Aug 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G D Roodman
Jun 11, 2002·Biochemical and Biophysical Research Communications·Helena BrändströmAndreas Kindmark
Jul 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bente L LangdahlErik Fink Eriksen

❮ Previous
Next ❯

Citations

Jan 12, 2011·Wiener medizinische Wochenschrift·Peter Mikosch, Derralynn Hughes
Jan 29, 2013·Hematology Reports·Gaetano GiuffridaFrancesco Di Raimondo
Nov 8, 2014·Calcified Tissue International·Gemma MarcucciMaria Luisa Brandi
Dec 7, 2011·Best Practice & Research. Clinical Rheumatology·P Mikosch
Nov 13, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Pascal GuggenbuhlGérard Chalès
May 15, 2007·Biochimica Et Biophysica Acta·Mariëlle J van BreemenFarhad Rezaee
Jun 3, 2021·Journal of Clinical Medicine·Margarita IvanovaOzlem Goker-Alpan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.