Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease

Journal of Orthopaedic Surgery and Research
Wei LianJun Yu

Abstract

Kashin-Beck disease (KBD) is an endemic, chronic, degenerative osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical symptoms, lacking of serological biomarkers. The serum level of PIICP, PIIANP, and PIIBNP can specifically reflect the damage of the cartilage. So, in this study, the serum levels of PIICP, PIIANP, and PIIBNP were detected in order to determine whether they can be used as potential biomarkers for the diagnosis of KBD. Using a status survey, the survey sites were selected in the KBD historical endemic areas and non-endemic areas in Jilin and Heilongjiang provinces. All local residents have undergone clinical examination, X-ray examination of the hands and knees, and questionnaire survey. A total of 554 people were surveyed, and 184 residents who are eligible for inclusion criteria were selected as our subjects. Fifty-six cases were diagnosed as KBD and 63 individuals were included as internal control and 65 subjects were included as external control. And blood samples of surveyed subjects were collected, and the serum was separated to detect the levels of PIICP, PIIANP, and PIIBNP by ELISA. Statistical analysis was performed using the SPSS software. There were no statistically significant di...Continue Reading

References

Aug 3, 2001·International Orthopaedics·F MathieuM Hinsenkamp
Aug 10, 2004·Methods in Molecular Medicine·Jean-Charles RousseauPatrick Garnero
Jun 17, 2010·Annals of the Rheumatic Diseases·Patricia A BerryFlavia M Cicuttini
Jul 31, 2013·Annals of the Rheumatic Diseases·M LotzJ-Y Reginster
Aug 16, 2017·Journal of Biomedical Research·Timothy McAlindonKlaus Flechsenhar
Nov 4, 2017·Rheumatology International·Tereza LennerováLadislav Šenolt
Feb 6, 2018·Rheumatology International·Rainer KlockeGeorge Hirsch

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay
ELISAs

Software Mentioned

SPSS

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