Serum levels of polychlorinated biphenyls and stroke risk among Chinese: a hospital-based case-control study.

Acta neurologica Belgica
Ping LiMei Lu

Abstract

Previous studies have revealed the serious human health risk effects of organic pollutants-polychlorinated biphenyls (PCBs). However, the roles of circulating PCBs on stroke risk have not been elucidated. The purpose of this study was to examine whether serum PCBs could increase the risk for stroke among Chinese participants. A total of 241 patients with stroke and age- (5-year interval) and gender-matched controls were recruited in Tianjin, China. Concentrations of 17 PCB congeners were measured by using high-resolution gas chromatography with mass spectrometric detection. Conditional logistic regression models were applied to assess the odds ratio (OR) and 95% confidential interval (CI). Significant positive associations were observed between serum total PCBs and dioxin-like PCBs and the risk for stroke (all p trends < 0.05), and the adjusted ORs for the highest tertile (T3) of serum concentration compared with the lowest tertile (T1) were 1.704 (1.073, 2.506) and 1.846 (1.156, 2.949). However, no significant association was found for non-dioxin-like PCBs (OR for T3 vs. T1: 1.388, 95%CIs: 0.850, 2.266; p trend: 0.118). Stratified analysis by stroke subtypes (ischemic or hemorrhagic strokes) showed no significant heterogeneity...Continue Reading

References

Jun 25, 2002·Toxicology and Applied Pharmacology·Bernhard HennigLarry W Robertson
Oct 25, 2002·International Journal of Toxicology·A Bernard, S Fierens
May 6, 2003·Journal of Environmental Monitoring : JEM·Stuart HarradAnthony Leeds
Oct 30, 2004·Human Reproduction·G M Buck LouisP J Kostyniak
Sep 1, 2005·Environmental Health : a Global Access Science Source·Ivan ShcherbatykhDavid O Carpenter
Sep 24, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Paul J KostyniakSusan L Schantz
Nov 18, 2005·Reproductive Toxicology·Sybille Pflieger-BrussWolf-Bernhard Schill
May 17, 2006·Reviews on Environmental Health·David O Carpenter
Jul 20, 2012·Environment International·Duk-Hee LeeLars Lind
Dec 5, 2013·The Journal of Biological Chemistry·Christoph F A VogelMichael S Denison
May 9, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Banrida WahlangMatthew C Cave
Nov 30, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yajie ChenSijun Dong
Apr 17, 2015·Environmental Science and Pollution Research International·Jordan T PerkinsBernhard Hennig
Nov 28, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Banrida WahlangMatthew C Cave
Jul 31, 2016·Environment International·Maria KipplerAgneta Åkesson
Dec 19, 2017·Environmental Pollution·Jung-Eun LimSun Ha Jee
Sep 29, 2019·Chemosphere·Michele MagoniUNKNOWN Brescia NHL-PCB Working Group

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