Serum levels of protein carbonyl, a marker of oxidative stress, are associated with overhydration, sarcopenia and mortality in hemodialysis patients.

BMC Nephrology
Young Rim SongEun-Kyoung Choi

Abstract

Increased oxidative stress in end-stage renal disease is regarded as one of the important mechanisms in the atherosclerosis and muscle wasting. However, studies examining the clinical significance of oxidative stress by direct measurement of these markers and its association with volume status and sarcopenia are limited. A follow-up cross-sectional study was performed in stable hemodialysis (HD) patients and serum protein carbonyl levels were measured as a biomarker of oxidative stress. Additionally, multi-frequency body composition analysis, handgrip strength (HGS) and nutritional assessments were performed at baseline. Eighty-eight patients undergoing HD were included and 30 (34.1%) patients died during a mean follow-up of 5.2 years. The mean patient age was 60.6 ± 13.5 years, and the mean HD duration was 50.8 ± 41.3 months. In total, 16 patients (18.2%) were overhydrated, 49 (55.7%) had low HGS and 36 (40.9%) had low muscle mass. Serum protein carbonyl levels were associated with serum levels of albumin, prealbumin and transferrin, hydration status and low HGS. Overhydration (odds ratio [OR] 7.01, 95% CI 1.77-27.79, p = 0.006), prealbumin (OR 0.91, 95% CI 0.83-0.99, p = 0.030), subjective global assessment (OR 3.52, 95% CI 1...Continue Reading

References

Mar 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J HimmelfarbR Hakim
Feb 1, 1996·Journal of Molecular and Cellular Cardiology·K PrasadB Bharadwaj
Dec 16, 1998·Journal of the American Society of Nephrology : JASN·T MiyataC van Ypersele de Strihou
Jan 21, 2000·Free Radical Biology & Medicine·M J DaviesR T Dean
Jul 8, 2000·Kidney International·A K CheungA S Levey
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M A SpittleN W Levin
May 2, 2002·Kidney International. Supplement·Marion MorenaBernard Canaud
Oct 10, 2002·Kidney International·Jonathan HimmelfarbRaymond M Hakim
Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael DanielskiJonathan Himmelfarb
May 28, 2004·Archives of Medical Research·Marlen Vicenté-MartínezRamón Paniagua
Jun 25, 2004·The New England Journal of Medicine·Stephen P McDonaldUNKNOWN Australian and New Zealand Paediatric Nephrology Association
Nov 4, 2004·American Journal of Nephrology·Hae Hyuk JungSang Hyun Lee
Oct 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Evangelia DounousiDimitrios Tsakiris
Aug 23, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco Galli
Dec 8, 2007·American Journal of Nephrology·Ioannis KaramouzisDimitrios M Grekas
May 7, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter WabelVolker Wizemann
Jan 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Volker WizemannDaniele Marcelli
Nov 28, 2009·Clinical Biochemistry·Kanti Bhooshan PandeySyed Ibrahim Rizvi
Dec 19, 2009·Seminars in Dialysis·Jonathan Himmelfarb
May 25, 2011·Journal of Nephrology·Barbara PavoneMario Bonomini
Jun 12, 2012·International Urology and Nephrology·Cheng Zhu, Peter R Mertens
Oct 19, 2012·Critical Care : the Official Journal of the Critical Care Forum·Suvi T VaaraUNKNOWN FINNAKI Study Group
Mar 2, 2013·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliUNKNOWN Lung US in CKD Working Group
Apr 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ibrahim H Fahal
Apr 23, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Daniele MarcelliUNKNOWN MONitoring Dialysis Outcomes (MONDO) Consortium
Aug 15, 2015·PloS One·Mihai OnofriescuAdrian Covic
Jul 31, 2016·International Urology and Nephrology·Beyza MacunluogluElif Ari
Oct 21, 2016·Seminars in Dialysis·Jonathan WongKen Farrington
Jan 19, 2017·Oncotarget·Mariana Janini GomesMarina Politi Okoshi
Nov 23, 2017·The Korean Journal of Internal Medicine·Jwa-Kyung KimYoung Rim Song
Jul 31, 2018·Oxidative Medicine and Cellular Longevity·Graziano ColomboIsabella Dalle-Donne
Sep 19, 2018·Annals of Nutrition & Metabolism·Hyung-Seok LeeYoung Rim Song
May 27, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Cheolsu KimYoung Rim Song

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Citations

Dec 31, 2020·Metabolites·Corina Daniela EneIlinca Nicolae
May 5, 2021·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Yun LiuYan Liu
Jul 3, 2021·Antioxidants·Nicoleta Bianca TudorachiElena Mihaela Cărăuşu
Sep 24, 2021·Biomarkers in Medicine·Hussein K Al-HakeimMichael Maes

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Methods Mentioned

BETA
ELISA
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X-ray

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