Serum levels of sclerostin in cardiometabolic disorders during pregnancy

Cytokine
Martin PlatzThomas Ebert

Abstract

Sclerostin has recently been introduced as a novel osteocyte-secreted factor which is associated with an adverse metabolic profile. However, regulation of circulating sclerostin in cardiometabolic disorders during pregnancy including gestational diabetes mellitus (GDM) and preeclampsia (PE) has not been comprehensively assessed, so far. Serum levels of sclerostin were quantified in 72 women with GDM and in 72 healthy, pregnant, gestational age-matched controls (study population 1). Furthermore, circulating sclerostin was assessed in 51 women with PE as compared to 51 pregnant controls in a second cohort (study population 2). In the first study population (GDM), median [interquartile range] sclerostin levels were not significantly different in women with GDM as compared to controls (GDM: 19.2 [8.1]pmol/l; controls: 18.6 [7.1]pmol/l; p=0.906). Interestingly, C reactive protein was a negative and independent predictor of circulating sclerostin in the GDM cohort in multivariate analysis. In study population 2 (PE), serum levels of sclerostin were not different between women with PE and controls (PE: 18.8 [9.2]pmol/l; controls: 19.3 [8.8]pmol/l; p=0.504). Furthermore, the osteocyte-secreted factor was not related to any metabolic an...Continue Reading

References

Mar 22, 2005·The Journal of Biological Chemistry·Xiaofeng LiDianqing Wu
May 26, 2009·Lancet·E Albert ReeceArnon Wiznitzer
Jul 6, 2010·Lancet·Eric A P SteegersRobert Pijnenborg
Sep 29, 2011·Clinical Endocrinology·Konstanze MiehleMathias Fasshauer
May 29, 2012·The Journal of Clinical Endocrinology and Metabolism·Tomohiko UranoSatoshi Inoue
Jan 5, 2013·Diabetes Care·Sonia Morales-SantanaManuel Muñoz-Torres
Feb 27, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Julia WildHarald Zeisler
Mar 29, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·T EbertM Fasshauer

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Citations

Jan 19, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Despina D BrianaAriadne Malamitsi-Puchner

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