Serum levels of soluble CD30 are increased in ulcerative colitis (UC) but not in Crohn's disease (CD)

Clinical and Experimental Immunology
R GiacomelliG Tonietti

Abstract

Imbalance in Th1 and Th2 subsets and their derived cytokines seems to be involved in the immune abnormalities underlying UC and CD. CD30 is a member of the tumour necrosis factor/nerve growth receptor superfamily expressed on T cells producing Th2 cytokines and released as a soluble form. In this study high levels of soluble CD30 were found in sera of UC patients independently of disease activity. Furthermore, increased titres of soluble CD30 molecule were shown, in the same patients, by mitogen-stimulated cultures of peripheral blood mononuclear cells. Our data seem to indicate that an activation of Th2 immune response is involved in the pathogenesis of UC, but not of CD. Furthermore, this finding indicates that serum soluble CD30 measurement may be helpful for differentiating these two forms of inflammatory bowel disease.

References

Jan 1, 1994·Annual Review of Immunology·S Romagnani
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Oct 29, 1955·British Medical Journal·S C TRUELOVE, L J WITTS

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Citations

Nov 18, 2000·Current Gastroenterology Reports·R C Fitzgerald, M J Farthing
Mar 28, 2012·Digestive Diseases and Sciences·Shinichi SomadaKenzaburo Tani
Nov 16, 2013·Immunologic Research·Hiromi Muta, Eckhard R Podack
Aug 13, 2003·Journal of Gastroenterology and Hepatology·Koji MatsuzakiSoichiro Miura
Jun 15, 2006·Immunology·Mary K KennedyRichard J Armitage
Dec 25, 2010·Therapeutic Advances in Gastroenterology·S D McLaughlinP J Ciclitira
Apr 18, 2001·Scandinavian Journal of Gastroenterology·P D ThomasP J Ciclitira
Mar 10, 2001·The American Journal of Gastroenterology·A Mandal, J Mayberry
Apr 22, 2005·The American Journal of Gastroenterology·Martin D GoughNigel C Bird
Feb 24, 2001·Autoimmunity·S Opat, J S Gaston

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