PMID: 2512170Nov 1, 1989Paper

Serum levels of soluble CD8 are increased in patients with B chronic lymphocytic leukemia

European Journal of Cancer & Clinical Oncology
G SemenzatoB Zuppini

Abstract

Serum levels of the soluble form of the CD8 (s-CD8) antigen were evaluated in the peripheral blood of 44 patients with B-CLL, using an enzyme-linked immunosorbent assay, and were correlated with clinical features and relevant hematological and immunological data. Increased values were observed with respect to normal age-matched controls (mean +/- S.E.M. 603 U/ml +/- 81 vs. 315 U/ml +/- 31, respectively; P less than 0.0001). This increase was observed in all stages of the disease, excluding stage 0 (mean 277 U/ml +/- 45). A general trend pointing to lower values overall in patients with less invasive disease was observed. In fact, the rank correlation test showed that the serum levels of s-CD8 correlate significantly with the WBC counts, the CD4/CD8 ratio, and also with the levels of serum immunoglobulins. On the contrary, no correlation was observed between s-CD8 levels and the absolute number of circulating CD8+ cells in individual cases. Therefore, the increase of s-CD8 is unlikely to be a mere expression of the increase of the CD8 cell number, but seems related to an increase of the activation phenomena involving the CD8+ T cell subset.

References

Dec 1, 1987·British Journal of Haematology·G PizzoloG Semenzato
Sep 1, 1983·The Journal of Experimental Medicine·J FujimotoR Levy

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Citations

Feb 17, 2009·American Journal of Respiratory and Critical Care Medicine·Elliott D CrouserCharis Eng
Jun 21, 2005·Blood Reviews·Farhad Ravandi, Susan O'Brien
Aug 16, 2005·American Journal of Respiratory and Critical Care Medicine·Carlo AgostiniGianpietro Semenzato
Mar 13, 2001·American Journal of Clinical Pathology·Z KaleemM M Zutter

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