Serum levels of soluble E-selectin in women with breast cancer

The British Journal of Surgery
S-M Sheen-ChenW-J Chen

Abstract

Increasing evidence suggests that E-selectin contributes to tumour growth and metastasis, possibly by increasing angiogenesis and the adhesion of tumour cells to endothelial cells at distant sites. This study aimed to examine the relationship between preoperative levels of circulating soluble E-selectin and breast cancer. Sixty-four consecutive women undergoing surgery for invasive breast cancer were studied prospectively. Venous blood samples were collected before the operation. A control group consisted of 16 patients with a benign breast tumour (eight with fibrocystic disease and eight with fibroadenoma). Serum concentrations of soluble E-selectin were measured by the quantitative sandwich enzyme immunoassay technique and compared with clinicopathological information. The mean (s.d.) serum level of soluble E-selectin in patients with invasive breast cancer was 73.7 (20.9) ng/ml, compared with 36.3 (5.6) ng/ml in the control group (P < 0.001). Furthermore, the serum levels of soluble E-selectin were significantly higher in women with oestrogen receptor-negative tumours (P = 0.001), poorly differentiated tumours (P < 0.001), more advanced primary tumour stage (P < 0.001), involved lymph nodes (P < 0.001), distant metastases (P...Continue Reading

References

Feb 1, 1994·Current Opinion in Immunology·R P McEver
May 16, 1995·International Journal of Cancer. Journal International Du Cancer·C YeH Takagi
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Feb 1, 1996·The Journal of Experimental Medicine·L BianconeI Stamenkovic
Oct 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C TempferC Kainz
Mar 1, 1997·American Journal of Hematology·K OkajimaK Takatsuki
Feb 7, 1998·The Journal of Surgical Research·C W WybleB L Gewertz

❮ Previous
Next ❯

Citations

Jan 1, 2009·Folia Histochemica Et Cytobiologica·M ManturD Lemancewicz
Mar 21, 2007·International Journal of Cancer. Journal International Du Cancer·Riccardo AlessandroGiacomo De Leo
Apr 12, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hye Won KangAlexei A Bogdanov
Mar 31, 2019·Interactive Cardiovascular and Thoracic Surgery·Tian JiangMingxiang Feng
Jul 25, 2009·Journal of Cellular and Molecular Medicine·Konstantinos A PaschosNigel C Bird
May 26, 2016·BMC Cancer·Shin-Ae KangTakemi Tanaka
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bhuvaneswari RamaswamyCharles L Shapiro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
B M WittigW Dippold
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
D M O'HanlonH F Given
Annals of the New York Academy of Sciences
M Yoshida, M A Gimbrone
© 2021 Meta ULC. All rights reserved