Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and the expression of ICAM-1 mRNA in uterine cervical cancer

Gynecologic Oncology
K NasuI Miyakawa

Abstract

The purpose of this investigation was to evaluate the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with squamous cell carcinoma of the cervix. Serum levels of sICAM-1 were measured by enzyme-linked immunosorbent assay in patients with cervical cancer (stage 0 through IV). Expression of mRNA in tumor tissues was evaluated by reverse transcriptase-polymerase chain reaction. Serum level of sICAM-1 in patients with advanced-stage (II-IV) or recurrent cervical cancer was found to be increased significantly. Expression of ICAM-1 mRNA was observed in most tumor tissues. Results suggest that sICAM-1 is shed from the cancerous tissue in patients with squamous cell carcinoma of the cervix.

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Citations

Dec 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jitti HanprasertpongThiti Atjimakul
Apr 10, 2008·International Journal of Cancer. Journal International Du Cancer·Fang WanLucia Pirisi
Dec 17, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jinke LiLina Hu
Jan 31, 2002·World Journal of Gastroenterology : WJG·Yong-Zhong LiuXi-Dian She
Jan 31, 2002·World Journal of Gastroenterology : WJG·Jing-Jing SunGe Zhou
Jan 31, 2002·World Journal of Gastroenterology : WJG·Jing-Jing SunYin-Kun Liu

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