Serum levels of soluble interleukin-2 receptors in acute and chronic viral hepatitis

Digestive Diseases and Sciences
A AlbertiG Pizzolo

Abstract

To analyze interleukin-2-dependent immunoregulatory function in hepatitis B virus infection and in other forms of viral hepatitis, levels of soluble interleukin-2 receptors (sIL-2R) were measured by an enzyme-linked assay in sera from patients with acute and chronic viral hepatitis of different etiology. Increased sIL-2R levels were detected in the early phase of acute hepatitis type A and type B, but not during acute non-A, non-B hepatitis. Among 46 patients with chronic hepatitis B virus infection, levels of sIL-2R were significantly increased only in cases with chronic active hepatitis, while they were about normal in chronic persistent hepatitis or in healthy carriers of the infection. These differences were independent of virus replication, being maintained when patients were stratified according to HBeAg/anti-HBe status and to serum HBV-DNA. Nine patients with chronic active hepatitis type B and high sIL-2R levels at presentation were followed prospectively for two to eight years, and in HBeAg-positive patients, the behavior of receptor levels closely paralleled disease activity. These results, which may reflect increased shedding of IL-2R by activated T lymphocytes in patients with active destruction of HBV infected hepa...Continue Reading

References

Aug 1, 1987·Journal of Hepatology·M CiveiraM Serrano
Jan 1, 1986·Digestion·P PontissoG Realdi
Aug 1, 1984·The Journal of Experimental Medicine·M TsudoH Uchino
May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L MontañoH C Thomas

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Citations

May 27, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Kaori KuramitsuYonson Ku
Feb 1, 1994·Journal of Hepatology·F PfeffelC Müller
Mar 10, 1998·Artificial Organs·K H ShuJ D Lian
May 1, 1996·The Journal of International Medical Research·H Simsek, A Kadayifci
Nov 1, 1990·Clinical and Experimental Immunology·F WagnerM Classen

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