Serum levels of the aminoterminal propeptide of type III procollagen and hyaluronan during resolving and nonresolving posttransfusion non-A, non-B hepatitis

Scandinavian Journal of Infectious Diseases
L MattssonB Aberg

Abstract

Serum levels of the aminoterminal propeptide of type III procollagen (PIIINP) and hyaluronan were analysed before and during the acute, recovery and chronic phases of non-A, non-B (NANB) posttransfusion hepatitis (PTH) in 13 patients. All patients were discovered during a prospective study on NANB PTH in patients undergoing open-heart surgery. 7/13 (54%) patients resolved their hepatitis within 6 months after onset, whereas 6/13 (46%) went on to chronic hepatitis. In 5 of these 6 patients a liver biopsy during the chronic phase of the hepatitis showed chronic active hepatitis in 2 and chronic persistent hepatitis in 3. During the acute NANB PTH phase the mean serum PIINP level rose significantly as compared to prehepatitis levels and to levels in a reference group not developing hepatitis. Neither PIIINP levels nor hyaluronan levels, however, could differentiate patients with resolving from patients with nonresolving hepatitis. These markers should, however, be further evaluated as potential markers for development of fibrosis/cirrhosis during chronic hepatitis.

References

Dec 1, 1979·European Journal of Clinical Investigation·H RohdeR Timpl
Jan 1, 1987·Acta Oto-laryngologica. Supplementum·R BrandtA Tengblad
Feb 1, 1986·Seminars in Liver Disease·J L Dienstag, H J Alter
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NybergL Lööf
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J McCulloughA J Czaja
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T FrébourgJ Bourreille
Oct 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·A Engström-LaurentT C Laurent
May 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ColomboC Tiribelli
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Engström-LaurentT Schröder
Jan 1, 1985·Journal of Hepatology·E G Hahn
Jan 1, 1980·The Biochemical Journal·A Tengblad
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FreiK Weigand
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K WeigandA Zimmermann

❮ Previous
Next ❯

Citations

Sep 17, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joseph George, Robert Stern
Nov 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·U Lindqvist, T C Laurent
Jun 1, 1996·Annals of Medicine·T C LaurentJ R Fraser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.