Serum levels of the interferon-gamma-inducing cytokine interleukin-18 are increased in individuals at high risk of developing type I diabetes

Diabetologia
F NicolettiR Gomis

Abstract

Interleukin (IL)-18 is a cytokine primarily produced by macrophages and capable of inducing T lymphocyte synthesis of interferon (IFN)-gamma. An up-regulated synthesis of IFN-gamma with consequential Type I cytokine dominance has been repeatedly shown in Type I (insulin-dependent) diabetes mellitus and thought to be involved in its pathogenesis. Because increased production of IFN-gamma could be secondary to a dysregulated synthesis of IL-18, we compared the circulating levels of IL-18 in patients with newly diagnosed Type I diabetes with those of non-diabetic first-degree relatives and healthy control subjects. Serum samples were obtained from healthy control subjects, patients with newly diagnosed Type I diabetes, and their healthy first-degree relatives. The latter were subdivided into "low" and "high" risk prediabetics depending on whether they were negative or positive for two or more of the anti-pancreatic autoantibodies ICA, GAD, IA-2 and IAA. Serum levels of IL-18 were measured by solid-phase ELISA. Interleukin (IL)-18 was above the detection limit of 25 pg/ml in 7 of 40 (17%) healthy control subjects, in 5 of 35 (14%) patients and in 3 of 30 (10%) first-degree relatives at low risk of developing Type I diabetes. In con...Continue Reading

Citations

Oct 25, 2002·Diabetes/metabolism Research and Reviews·Guido MeierhoffNanette C Schloot
May 5, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Paola ZacconeFerdinando Nicoletti
Dec 9, 2003·European Journal of Pharmacology·Heiko MühlJosef Pfeilschifter
Mar 26, 2003·Cytokine & Growth Factor Reviews·D ZaguryR C Gallo
Nov 19, 2004·Current Opinion in Hematology·Pavan Reddy
Jan 12, 2007·Genes and Immunity·S R Thompson, S E Humphries
May 20, 2004·Kidney International·Ravi Raju TatapudiManikkam Suthanthiran
Feb 20, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pilar LondonoDanny Zipris
Mar 31, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Travis R WolterDanny Zipris
Dec 18, 2003·Annals of the New York Academy of Sciences·Rúna L NolsøeThomas Mandrup-Poulsen
Apr 20, 2007·Developmental Neurobiology·Xiaohong ZhouWei Cao
Jan 26, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·Y HiromatsuT Bednarczuk
May 29, 2008·Clinical and Experimental Immunology·R L Rabin, A I Levinson
Feb 24, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·Z MojtahediA Ghaderi
Jan 26, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·P Hanifi-MoghaddamN C Schloot
Oct 7, 2004·European Journal of Pharmacology·Heiko Mühl, Josef Pfeilschifter
Jan 13, 2015·Molecular Immunology·Robert Z HarmsNora E Sarvetnick
Apr 30, 2003·Diabetes·Pejman Hanifi-MoghaddamHubert Kolb
Feb 1, 2012·The Journal of International Medical Research·Y B WangY Zhang
Jun 26, 2007·Journal of Dental Research·A OrozcoG J Seymour
Jul 31, 2013·Cellular and Molecular Life Sciences : CMLS·Saikiran K SedimbiMikael C I Karlsson
Mar 9, 2004·Postȩpy higieny i medycyny doświadczalnej·Marek Fol, Teresa Gościcka
Jun 30, 2005·The Journal of Biological Chemistry·Xiaohong ZhouWei Cao
Jun 13, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José Luiz Marques-RochaAmelia Marti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.