PMID: 15365314Sep 15, 2004Paper

Serum levels of tissue polypeptide specific antigen are correlated with hepatocyte cytokeratin expression in alcoholic liver disease

Alcoholism, Clinical and Experimental Research
Arturo Gonzalez-QuintelaJ Forteza

Abstract

Serum levels of the tumor marker tissue polypeptide specific antigen (TPS, cytokeratin 18 fragments) are increased in patients with alcoholic liver disease, particularly in cases of alcoholic hepatitis. Mallory bodies, characteristic of alcoholic hepatitis, are cytokeratin 8 and 18 aggregates. The study was aimed at investigating the possible relationship of serum TPS levels with hepatocyte cytokeratin expression in patients with alcoholic liver disease. Twenty-four patients with alcoholic liver disease were studied. Immunohistochemical staining for cytokeratins 8 and 18 was performed in liver specimens by means of CAM 5.2 monoclonal antibody. The number of hepatocytes containing CAM 5.2-reactive cytokeratin inclusions was compared with serum TPS levels. The vast majority of alcoholics (95%) showed increased (>100 units/liter) serum TPS levels. Serum TPS levels were significantly correlated with the number of hepatocyte cytokeratin inclusions. Serum TPS levels can predict hepatocyte cytokeratin expression in patients with alcoholic liver disease.

References

Jan 1, 1994·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·J M BonfrerD Ivanyi
Jun 1, 1993·Liver·P Van Eyken, V J Desmet
Jan 31, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·D MoraglioL Bertero
Oct 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·J CollazosA Ruibal
Mar 21, 1998·Virchows Archiv : an International Journal of Pathology·P SchirmacherR Moll
Oct 19, 1999·Thyroid : Official Journal of the American Thyroid Association·S SuzukiA Tsuchiya
Sep 1, 2000·Alcoholism, Clinical and Experimental Research·A González-QuintelaS Lojo
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G Buccheri, D Ferrigno
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Bishr OmaryDiana M Toivola
Apr 23, 2002·Journal of Cellular Biochemistry·Michael A SheardDalibor Valik
Aug 28, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BerglundB Glimelius
Jul 25, 2003·Alcoholism, Clinical and Experimental Research·Hiromasa IshiiAmin A Nanji

❮ Previous
Next ❯

Citations

Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arturo Gonzalez-QuintelaLuls F Perez
Jun 21, 2011·Alcoholism, Clinical and Experimental Research·Arturo Gonzalez-QuintelaFrancisco Gude
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Arturo Gonzalez-QuintelaEsteban Otero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan
Ren-Jeng PeiAiro Tsubura
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M Bishr OmaryDiana M Toivola
© 2021 Meta ULC. All rights reserved