Serum levels of TNF-α, IL-12/23p40, and IL-17 in plaque psoriasis and their correlation with disease severity

Journal of Immunology Research
Aikaterini KyriakouDimitrios Sotiriadis

Abstract

A case-control study was performed to assess the serum levels of TNF-α, IL-12/23p40, and IL-17 in patients with plaque psoriasis, compare them with healthy controls, and correlate them with disease severity, as represented by Psoriasis Area Severity Index (PASI). 32 consecutively selected, untreated patients with active, chronic plaque psoriasis were recruited and compared to 32 age- and sex-matched healthy controls. Serum cytokine levels were determined by solid phase sandwich enzyme linked immunosorbent assay (R&D Systems Europe, Ltd.). The mean serum levels of TNF-α were significantly higher in psoriatic patients compared to those of controls (Mann-Whitney U test; P = 0.000). However, the median serum levels of neither IL-12/23p40 nor IL-17 differ significantly between the 2 groups (Mann-Whitney U test; P = 0.968 and P = 0.311, resp.). No significant correlations were found between PASI and any of the cytokine serum levels (Spearman's rank test; P > 0.05). Despite the well-evidenced therapeutic efficacy of biologic agents targeting TNF-α, IL-12/23p40, and IL-17, serum levels of TNF-α, IL-12/23p40, and IL-17 do not seem to correlate with the severity of psoriatic skin disease in untreated patients, as represented by PASI. Fur...Continue Reading

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Citations

Sep 25, 2020·Critical Reviews in Food Science and Nutrition·Luigi BarreaGiovanna Muscogiuri
Nov 23, 2017·Frontiers in Immunology·Amara EzeonyejiMichael R Ehrenstein
Apr 12, 2018·Anais Brasileiros De Dermatologia·Mahnaz MansouriZohreh Jadali
Apr 22, 2016·Free Radical Research·Xiran Lin, Tian Huang
Dec 8, 2016·Clinical and Experimental Dermatology·X Y ZhouY Jin
Apr 29, 2020·Annual Review of Immunology·Nico GhilardiAndrew C Chan
Dec 22, 2020·Frontiers in Immunology·Vera PlužarićStana Tokić
Jan 1, 2018·Anais Brasileiros De Dermatologia·Mahnaz MansouriZohreh Jadali
Apr 27, 2021·The Journal of International Medical Research·Nergez Sabah OmarXuebiao Peng

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Methods Mentioned

BETA
enzyme linked immunosorbent assay

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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