Serum lipid and lipoprotein abnormalities in human African trypanosomiasis

Transactions of the Royal Society of Tropical Medicine and Hygiene
G HuetP Degand

Abstract

We have studied the serum lipoprotein system in human African trypanosomiasis (Trypanosoma brucei gambiense infection). The study was carried out on 74 Congolense patients suffering from sleeping sickness and 34 Congolense control subjects living in the endemic region of Boko Songho. We have determined the serum concentrations of lipids (triglycerides, cholesterol, phospholipids) and apolipoproteins (apolipoprotein A-I and B), and the separation of serum lipoproteins by electrophoresis. For the patients infected with T. b. gambiense, in comparison with control subjects, the results have shown (i) a significant increase in triglyceride concentration and a decrease in cholesterol concentration; (ii) a significant rise in apolipoprotein B concentration and a significant reduction in apolipoprotein A-I concentration; and (iii) an increase in low density lipoproteins and a decrease in high density lipoproteins. We conclude, therefore, that human African trypanosomiasis is associated with marked alterations in the composition and levels of host lipoproteins.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M R Rifkin
Jan 1, 1975·Transactions of the Royal Society of Tropical Medicine and Hygiene·S A Olowe
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·A BoersmaP Degand
Nov 1, 1987·The Journal of protozoology·I CoppensP Baudhuin
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I CoppensP J Courtoy
Jun 1, 1973·Parasitology·L G Goodwin, M W Guy
Feb 1, 1984·European Journal of Clinical Investigation·E MulsP de Moor

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Citations

Mar 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·V W Pentreath
May 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·B J Berger, A H Fairlamb
Jan 1, 1995·Molecular and Biochemical Parasitology·E M TytlerS L Hajduk
Jun 14, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hamidou IlboudoBruno Bucheton
Oct 28, 2015·PLoS Neglected Tropical Diseases·Sabrina D LamourJeremy M Sternberg

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