PMID: 16507398Mar 2, 2006Paper

Serum lipid profiles in patients receiving endocrine treatment for breast cancer--the results from the Celecoxib Anti-Aromatase Neoadjuvant (CAAN) Trial

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Louis W C ChowMasakazu Toi

Abstract

Anti-aromatase therapy is important in the treatment of breast cancer. Cyclooxygenase-2 (COX-2) inhibitors may be effective in chemoprevention. A proof of principle study was performed to investigate the efficacy and side effects including changes in lipid profiles of combining anti-aromatase therapy and COX-2 inhibitor preoperatively in hormone sensitive postmenopausal breast cancers. From February 2002 to April 2003, 41 postmenopausal women with histologically proven LABC were recruited. The patients were randomly assigned to receive exemestane 25 mg daily and celecoxib 400 mg twice-daily (group A), exemestane 25 mg daily (group B) and letrozole 2.5 mg daily (group C. Observed clinical response rates were 61.5%, 60% and 54.5% for Groups A-C, respectively, with no pathologic complete response. Cholesterol levels for Group A dropped progressively and a statistical difference was observed between fifth week after operation and preoperative level (P = 0.026). In addition, Group A has significantly lowered cholesterol and LDL levels than Groups B and C after 18 weeks of treatment. The initial results show that different neoadjuvant anti-aromatase therapies has similar efficacy but the combination with celecoxib may have an advanta...Continue Reading

References

Dec 15, 1991·The New England Journal of Medicine·M J ThunC W Heath
Sep 7, 1995·The New England Journal of Medicine·E GiovannucciF E Speizer
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Citations

Feb 12, 2009·Disease Markers·Shwayta KukretiEnrico Gratton
Jun 3, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Louis Wing-Cheong ChowMasakazu Toi
Jun 12, 2019·Lipids in Health and Disease·Xuefeng GuanYu Ding

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