Serum lipids, acute phase proteins and serum cholinesterase in normal subjects

Scandinavian Journal of Clinical and Laboratory Investigation
M CrookP Tutt

Abstract

Although serum cholinesterase (CHE) is elevated in some hyperlipidaemic subjects, the relationship between serum CHE and lipids in normolipidaemic subjects is scanty. Furthermore, serum CHE is reduced in conditions in which there is an acute phase response. Serum CHE activity was measured in 46 normal individuals (22 males and 24 females). There was no significant difference between the activity of serum CHE in males or females being 6.2 +/- 1.8 U1(-1) vs. 6.4 +/- 1.5 U1(-1) respectively (mean +/- SD). There was, however, a significant correlation between serum CHE and subject age (Spearman rho 0.35, p < 0.05). There was also a significant correlation between serum CHE and serum nonfasting triglyceride concentration (rho 0.34, p < 0.05) and also apolipoprotein B (rho 0.38, p < 0.05) but not serum cholesterol or HDL-cholesterol. Five serum acute phase proteins were measured namely serum alpha-1 antichymotrypsin (ACT), alpha-1-acid-glycoprotein (AGP), alpha-2-macroglobulin (AMG), C-reactive protein (CRP), haptoglobin (HAP). Only serum AGP showed a significant negative correlation with serum CHE (rho - 0.43, p < 0.02).

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Citations

Mar 16, 2011·Clinical Biochemistry·Marina StojanovMilica Prostran
Apr 2, 2005·Current Medical Research and Opinion·Annie H ShinnTimothy J Smith
Apr 22, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Vânia M AlcântaraEleidi A Chautard-Freire-Maia
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Mar 19, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Saman MohammadiBijan Esmaeilnejad

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