Serum lipids and hepatic microsomal enzymes with special reference to serum cholinesterase in Wistar rats

General Pharmacology
U Nousiainen, R Ryhänen


Serum pseudocholinesterase in accordance with indicators revealing the lipid metabolism and liver function was studied in rats exposed to phenobarbital, bis-p-nitrophenylphosphate and disulfiram in vivo. Phenobarbital markedly induced the hepatic microsomal drug-metabolizing enzymes and tended to decrease the triglyceride content in serum. Serum lipids remained almost unaffected after the treatment of bis-p-nitrophenylphosphate. However, serum gamma-glutamyltransferase activity showed a marked decrease to this organophosphorus compound. Disulfiram activated the microsomal UDP-glucuronosyltransferase (p-nitrophenol) activity, and caused an enhancement of serum total cholesterol, which suggests that this drug might be atherogenic.


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Jan 1, 1984·The International Journal of Biochemistry·R RyhänenE Puhakainen
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Related Concepts

Sodium nitrophenylphosphate
Enzyme Induction
Mixed Function Oxygenases
Microsomes, Liver
Organopyrophosphorus Compounds

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