Serum lipids in hypothyroidism--a re-evaluation

The Journal of Clinical Endocrinology and Metabolism
K M KuttyN R Farid


One hundred and forty-two persons referred for assessment of thyroid function were studied in relation to their thyroid function and fasting serum lipids. Forty-five individuals, who had no family history of thyroid disease, were euthyroid, and were negative for thyroid antibodies formed the control group. The remaining 97 patients were fitted into six groups as follows--euthyroid Hashimoto's thyroiditis, thyroiditis with exagggerated TSH response to TRH, and four groups of increasing grades of thyroid failure based on the level of serum TSH. Only in the two most severely hypothyroid groups was cholesterol significantly elevated as compared with control levels. A graded increase in mean serum triglyceride, was observed as thyroid failure increased; however, values were not different (P greater than 0.05) from the control group. However, partial correlation analysis indicated that serum cholesterol was related to increasing levels of serum TSH and that this dependency was not influenced by age or weight. Although serum cholesterol was related to thyroid function in the study population, it was an insensitive indicator of the metabolic effects of thyroid hormone.


Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R E IbrahimI A Wasfi
Mar 1, 1996·Trends in Endocrinology and Metabolism : TEM·J A Franklyn, M D Gammage
Jun 30, 2000·Endocrinology and Metabolism Clinics of North America·A R AyalaP W Ladenson
Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·P J Leslie, A D Toft
Jul 21, 1994·The New England Journal of Medicine·A D Toft
Mar 12, 1998·The New England Journal of Medicine·J A FranklynP Boyle
Mar 28, 2003·Surgery·Johanna LaukkarinenIsto Nordback
Jan 1, 1986·Journal of the American College of Nutrition·W A ForsytheJ J Anderson
May 30, 2002·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas
Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Robert Deicher, H Vierhapper
Dec 29, 2000·Thyroid : Official Journal of the American Thyroid Association·H VierhapperA Gessl
May 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Till IttermannHenry Völzke
Nov 1, 1992·Clinical Endocrinology·J V ParleM C Sheppard
Oct 1, 1995·Clinical Endocrinology·A W KungE D Janus
Jul 1, 1979·The Journal of Clinical Investigation·W G Keyes, M Heimberg
Sep 1, 1993·Mayo Clinic Proceedings·T O'BrienP J Palumbo
Mar 27, 2012·The Medical Clinics of North America·Leonidas H Duntas, Gabriela Brenta
May 8, 2010·Clinical Endocrinology·Stephan RuhlaMatthias Möhlig
Jan 6, 2005·Archives of Medical Research·Won-Young LeeSun-Woo Kim
Feb 1, 1982·Clinical Biochemistry·M AviramJ G Brook
Aug 1, 1980·Metabolism: Clinical and Experimental·T Murase, H Uchimura
Dec 1, 1979·The Journal of Surgical Research·O H ClarkA L Jones
Jan 1, 1985·Clinical Endocrinology·G M BellA D Toft
Apr 1, 1985·The Journal of Pediatrics·S LaFranchiD R Illingworth
Oct 11, 2012·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Johanna LaukkarinenIsto Nordback
Dec 2, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lucia PacificoClaudio Chiesa
May 1, 1993·Clinical Endocrinology·J A FranklynM C Sheppard
Oct 28, 2016·The American Journal of Chinese Medicine·Sang-In ParkSae-Kwang Ku
Jul 13, 2012·Journal of Atherosclerosis and Thrombosis·Satomi MugiiShizuya Yamashita
Dec 1, 1987·The British Journal of Surgery·J PowellP B Fowler
Oct 1, 1982·European Journal of Clinical Investigation·S ValdemarssonP Nilsson-Ehle
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·M WeintraubN Stern
Dec 7, 2006·The Journal of Clinical Endocrinology and Metabolism·Mitsuru ItoAkira Miyauchi
Apr 1, 1988·Journal of Endocrinological Investigation·P KöltringerP Lind
Dec 13, 2003·Journal of Endocrinological Investigation·F AziziM Arabi
May 1, 1982·Postgraduate Medicine·S S StofferM R Block
Jul 22, 2018·Journal of Health, Population, and Nutrition·Habtamu Azene TekleFithamlak Bisetegen Solomon
Jan 1, 1982·Acta Medica Scandinavica·B Hylander, U Rosenqvist

Related Concepts

Thyroid Hormones
Proterelin Tartrate Hydrate

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

The Journal of Clinical Investigation
E A Nikkilä, M Kekki
The Journal of Clinical Investigation
Thyroid : Official Journal of the American Thyroid Association
Leonidas H Duntas, Leonard Wartofsky
© 2021 Meta ULC. All rights reserved