Abstract
The association between angiographically defined coronary artery disease (CAD) and serum lipids, lipoproteins, and apolipoproteins was evaluated in 151 black men and 245 black women. Patients with 70% or greater narrowing of at least one coronary artery or greater than or equal to 50% stenosis of the left main coronary artery (n = 179) were compared to those with lesions of less than 50% stenosis (n = 217) for total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), LDL-C/HDL-C, triglycerides, apolipoprotein A-I, apolipoprotein B, and apolipoprotein A-I/B. A consistently more atherogenic pattern of lipids, lipoproteins, and apolipoproteins occurred only among the women. Using stepwise selection multiple logistic regression analysis, the ratio of apolipoprotein A-I/B (odds ratio = 0.38, 95% confidence limits 0.24-0.61) was the only statistically significant association of CAD in women, after adjusting for the effects of age, body mass index, and histories of smoking, hypercholesterolemia, hypertension, and diabetes. When stratified by median of total cholesterol, the ratio of apolipoprotein A-I/B was the most strongly associated with the presence of CAD in the lower half ...Continue Reading
References
Jun 1, 1976·Metabolism: Clinical and Experimental·J J AlbersJ J Hoover
Jul 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·C VerganiN Dioguardi
May 1, 1986·Circulation·S P SedlisG Schonfeld
Nov 7, 1986·JAMA : the Journal of the American Medical Association·D M DeLongB M Rifkind
May 28, 1987·The New England Journal of Medicine·S Paulin
Jul 1, 1986·Circulation·C MaynardT Pullum
Dec 1, 1986·Atherosclerosis·A AroM Wiljasalo
May 1, 1985·Circulation·M F ReardonR W Harper
Aug 18, 1983·The New England Journal of Medicine·J J MaciejkoS J Mao
Aug 18, 1983·The New England Journal of Medicine·H Blackburn
May 1, 1984·Atherosclerosis·H KukitaT Kokubu
Sep 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·G FagerG Bondjers
May 30, 1981·British Medical Journal·N E MillerB Lewis
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A SnidermanP O Kwiterovich
Jun 1, 1981·Atherosclerosis·T F WhayneE Schechter
Sep 1, 1980·Atherosclerosis·W F RiesenH P Gurtner
Jan 1, 1981·Atherosclerosis·G M KostnerG B Qunici
Citations
May 30, 1998·The American Journal of Cardiology·R F GillumC T Sempos
Jan 1, 1994·Genetic Epidemiology·A E LaingA J Lusis
Apr 25, 1992·The American Journal of Cardiology·P O KwiterovichT A Pearson
Mar 22, 2006·Disease-a-month : DM·Enas A EnasV Mohan
Jan 1, 1993·Genetic Epidemiology·J CoreshP O Kwiterovich
Jul 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A R SharrettC E Davis
Oct 28, 2003·Clinical Chemistry·Jiri Frohlich, Milada Dobiásová