Serum lipoproteins, lipid peroxides and prostacyclin biosynthesis in patients with coronary heart disease

Prostaglandins
A SzczeklikT Gryglewska

Abstract

Serum low-density lipoproteins (LDL) and high-density lipoproteins (HDL) were prepared by gradient ultracentrifugation and dialysis from 12 healthy subjects and 15 patients with coronary heart disease and hyperlipoproteinemia. In both lipoprotein fractions cholesterol and lipid peroxides were determined. The effect of these lipoproteins on spontaneous prostacyclin biosynthesis in rat aortic slices was studied. Serum lipoproteins were susceptible to peroxidation during the preparation procedure. LDL were more prone to peroxidation than HDL. Little lipid peroxides were formed in lipoproteins when calcium ions had been removed by EDTA, and when butylated hydroxytoluene (BHT) was present at all stages of their preparation. LDL when prepared without these precautions either from healthy subjects or from patients with coronary heart disease markedly suppressed prostacyclin generation by rat aortic slices. This inhibition was unrelated to LDL-cholesterol, but was due to LDL-lipid peroxides. Peroxide-low LDL prepared from most of the healthy subjects and patients with coronary heart disease and concomitant hyperlipoproteinemia, did not inhibit prostacyclin biosynthesis. However, in one quarter of the patients, LDL was inhibitory. Conse...Continue Reading

References

Sep 1, 1979·Lancet·H SinzingerK Silberbauer
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J SchuhR H Haschemeyer
Nov 1, 1979·Analytical Biochemistry·M Hicks, J M Gebicki
Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Satoh
Nov 15, 1980·Lancet·H Zygulska-MachR J Gryglewski
Jul 1, 1980·Thrombosis Research·A SzczeklikR Korbut
Mar 21, 1981·Lancet·L O Carreras, J Vermylen
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A M FogelmanP A Edwards
Aug 29, 1980·Biochemical and Biophysical Research Communications·D M Lee

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Citations

Jan 1, 1987·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S M WeiZ Y Wang
Apr 29, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·Z S HuangT K Lee
Oct 15, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·H PlachtaA Obara
Apr 15, 1985·Thrombosis Research·P HenrikssonO Edhag
May 1, 1986·Prostaglandins, Leukotrienes, and Medicine·C GiesslerW Förster
Mar 1, 1987·Prostaglandins, Leukotrienes, and Medicine·J L Toivanen
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·W E Lands
Oct 17, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·D KonukoğluB Oner
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·B HennigE A Decker
Jul 1, 1995·Pharmacology & Toxicology·N M IsmailS Hashim
Feb 4, 1989·BMJ : British Medical Journal·M D StringerV V Kakkar
Jun 1, 1983·Journal of Clinical Pathology·J AznarJ Sala
Aug 1, 1992·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R Dargel
Feb 1, 1989·Annals of Medicine·J T Salonen
Jul 4, 2001·BMC Clinical Pathology·Adriana E ScocciaAna María Cortizo
Feb 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J D Symons
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K B Pomerantz, D P Hajjar
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J E TriauE J Schaefer
Jan 1, 1983·Acta Medica Scandinavica·A NordøyR A Lenner

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