Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional Study

Gastroenterology Research and Practice
Xingshun QiXiaozhong Guo

Abstract

Background and Aims. A retrospective cross-sectional study was conducted to evaluate the role of hyaluronic acid (HA), laminin (LN), amino-terminal propeptide of type III procollagen (PIIINP), and collagen IV (CIV) in predicting the presence of gastroesophageal varices (GEVs) in patients with liver cirrhosis. Methods. We enrolled 118 patients with liver cirrhosis who underwent the tests for the four serum liver fibrosis markers and upper gastrointestinal endoscopy at the same admissions. The predictive values of the four serum liver fibrosis markers were evaluated by the areas under the receiving operator characteristics curves (AUROCs) with 95% confidence intervals (CIs). Results. The prevalence of GEVs was 88% (104/118). The AUROCs for HA, LN, PIIINP, and CIV levels in predicting the presence of GEVs were 0.553 (95% CI: 0.458 to 0.644, P = 0.5668), 0.490 (95% CI: 0.397 to 0.584, P = 0.9065), 0.622 (95% CI: 0.528 to 0.710, P = 0.1099), and 0.560 (95% CI: 0.466 to 0.652, P = 0.4909). The PIIINP level at a cut-off value of 31.25 had a sensitivity of 73.1% and a specificity of 57.1%. Conclusions. The present study did not recommend HA, LN, PIIINP, and CIV levels to evaluate the presence of GEVs in liver cirrhosis.

References

Dec 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M GressnerK H Pick-Kober
Feb 15, 2001·Current Gastroenterology Reports·S Oh, N H Afdhal
Sep 20, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Apr 9, 2008·Gastroenterology·Mireen Friedrich-RustEva Herrmann
Jul 14, 2009·Journal of Clinical Gastroenterology·Elliot SchwarzenbergerAlbert D Min
Mar 5, 2010·The New England Journal of Medicine·Guadalupe Garcia-Tsao, Jaime Bosch
Apr 20, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter JarcuskaLubomír Skladaný
Jul 20, 2011·Journal of Hepatology·Laurent CasteraJaime Bosch
Mar 14, 2012·European Journal of Gastroenterology & Hepatology·Saurabh ChawlaRajender Agarwal
Sep 15, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Ke-Qing ShiMing-Hua Zheng
Aug 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Annalisa BerzigottiThomas D Boyer
Sep 17, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrea LisottiGiuseppe Mazzella
Apr 1, 2014·Clinics in Liver Disease·Roberto de Franchis, Alessandra Dell'Era
Apr 26, 2014·World Journal of Gastroenterology : WJG·Moon Young KimSoon Koo Baik
Oct 12, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRichard L Ehman
Nov 2, 2014·United European Gastroenterology Journal·Vipin VermaAshish Kumar
Dec 11, 2014·World Journal of Gastroenterology : WJG·Horia Stefanescu, Bogdan Procopet
Dec 17, 2014·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Hasan S MahmoudMohammed A W Mohammed

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Citations

Sep 1, 2015·PloS One·Gloria Sanchez-AntolínJesus F Bermejo-Martin
Sep 22, 2016·The American Journal of the Medical Sciences·Jiancheng ZhaoXiaozhong Guo
Sep 27, 2018·Scandinavian Journal of Gastroenterology·Kei EndoYasuhiro Takikawa
Aug 3, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xingshun QiXiaozhong Guo
Mar 25, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xintong ZhangXiaozhong Guo
Jan 27, 2017·Experimental and Therapeutic Medicine·Yun LiXiaozhong Guo
May 22, 2018·BioMed Research International·Klaudia MazurekJarosław Markowski
Apr 12, 2021·Clinics in Liver Disease·Élise Vuille-LessardAnnalisa Berzigotti

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