Serum magnesium and cardiovascular mortality in peritoneal dialysis patients: a 5-year prospective cohort study

The British Journal of Nutrition
Hongjian YeXiao Yang

Abstract

The aim of this study was to explore the association between serum Mg and cardiovascular mortality in the peritoneal dialysis (PD) population. This prospective cohort study included prevalent PD patients from a single centre. The primary outcome of this study was cardiovascular mortality. Serum Mg was assessed at baseline. A total of 402 patients (57 % male; mean age 49·3±14·9 years) were included. After a median of 49·9 months (interquartile range: 25·9-68·3) of follow-up, sixty-two patients (25·4 %) died of CVD. After adjustment for conventional confounders in multivariate Cox regression models, being in the lower quartile for serum Mg level was independently associated with a higher risk of cardiovascular mortality, with hazards ratios of 2·28 (95 % CI 1·04, 5·01), 1·41 (95 % CI 0·63, 3·16) and 1·62 (95 % CI 0·75, 3·51) for the lowest, second and third quartiles, respectively. A similar trend was observed when all-cause mortality was used as the study endpoint. Further analysis showed that the relationships between lower serum Mg and higher risk of cardiovascular and all-cause mortality were present only in the female subgroup, and not among male patients. The test for interaction indicated that the associations between lowe...Continue Reading

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Citations

Sep 27, 2020·Antioxidants·Man Liu, Samuel C Dudley
Mar 1, 2019·Nutrients·Nicoline H J Leenders, Marc G Vervloet
Jan 10, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicoline H J LeendersMarc G Vervloet
Jun 17, 2021·Hemodialysis International·Christopher Holzmann-LittigDominik Steubl
Aug 28, 2021·International Journal of Molecular Sciences·Marie-Eva Pickering

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