Serum Magnesium and the Risk of Death From Coronary Heart Disease and Sudden Cardiac Death

Journal of the American Heart Association
Brenda C T KieboomEwout J Hoorn

Abstract

Low serum magnesium has been implicated in cardiovascular mortality, but results are conflicting and the pathway is unclear. We studied the association of serum magnesium with coronary heart disease (CHD) mortality and sudden cardiac death (SCD) within the prospective population-based Rotterdam Study, with adjudicated end points and long-term follow-up. Nine-thousand eight-hundred and twenty participants (mean age 65.1 years, 56.8% female) were included with a median follow-up of 8.7 years. We used multivariable Cox proportional hazard models and found that a 0.1 mmol/L increase in serum magnesium level was associated with a lower risk for CHD mortality (hazard ratio: 0.82, 95% CI 0.70-0.96). Furthermore, we divided serum magnesium in quartiles, with the second and third quartile combined as reference group (0.81-0.88 mmol/L). Low serum magnesium (≤0.80 mmol/L) was associated with an increased risk of CHD mortality (N=431, hazard ratio: 1.36, 95% CI 1.09-1.69) and SCD (N=217, hazard ratio: 1.54, 95% CI 1.12-2.11). Low serum magnesium was associated with accelerated subclinical atherosclerosis (expressed as increased carotid intima-media thickness: +0.013 mm, 95% CI 0.005-0.020) and increased QT-interval, mainly through an effec...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·H Orimo, Y Ouchi
Sep 18, 1997·The American Journal of Cardiology·R J MyerburgA Castellanos
Sep 10, 1999·International Journal of Epidemiology·E S Ford
Aug 3, 2001·European Heart Journal·S G PrioriD P Zipes
Dec 6, 2003·Stroke; a Journal of Cerebral Circulation·Jasmin AmighiMartin Schillinger
Mar 5, 2004·The New England Journal of Medicine·Dan M Roden
May 26, 2004·Biochimica Et Biophysica Acta·Jeanette A M MaierAndrzej Mazur
Mar 5, 2005·Stroke; a Journal of Cerebral Circulation·Michiel L BotsJacqueline C M Witteman
Mar 17, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Daniela BernardiniJeanette A M Maier
Jan 18, 2006·Journal of the American College of Cardiology·Sabine M J M StrausJacqueline C M Witteman
Apr 25, 2006·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Brian F McBrideC Michael White
Aug 2, 2008·International Journal of Cardiology·Chris AdamopoulosAli Ahmed
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Aug 12, 2010·PLoS Genetics·Tamra E MeyerUNKNOWN Meta Analysis of Glucose and Insulin Related Traits Consortium
Oct 12, 2010·American Heart Journal·Abigail May KhanThomas J Wang
Nov 26, 2010·The American Journal of Clinical Nutrition·Stephanie E ChiuveChristine M Albert
Mar 6, 2012·European Journal of Epidemiology·Maarten J G LeeningJacqueline C M Witteman
Jan 22, 2013·The American Journal of Medicine·George LiamisEwout J Hoorn
Mar 30, 2013·Journal of the American Heart Association·Stephanie E ChiuveChristine M Albert
May 31, 2013·The American Journal of Clinical Nutrition·Liana C Del GobboDariush Mozaffarian
Apr 11, 2014·American Journal of Physiology. Renal Physiology·Zheng ZhangDavid M Cohen
Oct 4, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Maartje N NiemeijerMark Eijgelsheim
Dec 30, 2014·Physiological Reviews·Jeroen H F de BaaijRené J M Bindels
Sep 21, 2015·European Journal of Epidemiology·Albert HofmanMeike W Vernooij

❮ Previous
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Citations

May 29, 2016·Trends in Cardiovascular Medicine·Marten E van den BergLies Lahousse
Feb 2, 2018·Nutrients·Nuria Rosique-EstebanJordi Salas-Salvadó
Oct 17, 2017·QJM : Monthly Journal of the Association of Physicians·A A A IsmailA A Ismail
Oct 28, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Silvia FerrèJavier A Neyra
Oct 25, 2017·European Journal of Epidemiology·M Arfan IkramAlbert Hofman
Jul 1, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Anique D Ter BraakeJeroen H F de Baaij
Feb 3, 2018·Scientific Reports·Anique D Ter BraakeJeroen H F de Baaij
Jun 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Anna SoliniRosa Maria Bruno
Nov 13, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Jéssica LevyDirce Maria Marchioni
Feb 2, 2020·Hospital Practice·Wisit CheungpasitpornStephen B Erickson
Sep 22, 2017·Neurology·Brenda C T KieboomM Arfan Ikram
Mar 9, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Steef KurstjensJeroen H F de Baaij
Jun 1, 2018·International Journal of Endocrinology·Abdullah M Al AlawiHenrik Falhammar
Apr 18, 2018·European Journal of Epidemiology·Sasiwarang Goya WannametheePeter H Whincup
Nov 17, 2019·The American Journal of Clinical Nutrition·Rob M van Dam
Nov 26, 2020·Journal of Clinical Medicine·Alyssa M B WhiteRonald D Hills
Dec 30, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anique D Ter BraakeJoost G J Hoenderop
Dec 19, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Hasan Abbas QazmoozMichael Maes
Dec 15, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·M V Pendón-Ruiz de MierM Rodríguez
Dec 5, 2020·Journal of Translational Medicine·Clementina SitziaMassimiliano Marco Corsi Romanelli
Dec 8, 2020·Frontiers in Cell and Developmental Biology·Cristian Rodelo-HaadMariano Rodríguez
Feb 16, 2021·Frontiers in Physiology·Yiheng YangYunlong Xia
Jun 8, 2021·Journal of the American Heart Association·Man LiuSamuel C Dudley
Jul 20, 2021·Endocrinology, Diabetes & Metabolism·Katherine M WangTara I Chang
Aug 8, 2021·International Journal of Environmental Research and Public Health·Jennifer ByrnePeter M Clifton

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Methods Mentioned

BETA
blood draw

Software Mentioned

SPSS Statistics
Modular ECG Analysis System ( MEANS )
R
cmprsk
R ( The R Foundation for Statistical Computing
MEANS

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