Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Hwal Rim JeongIl Tae Hwang

Abstract

This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12 months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p = .005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p < .05), while the MKRN3 concentrations were unchanged (p > .05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r = -0.46, p = .000), SD in weight (r = -0.32, p = .005), Tanner stage (r = -0.41, p = .000), and bone age (r = -0.46, p = .000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation.

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Oct 11, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hwal Rim JeongJin Soon Hwang

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Citations

Jul 21, 2020·The Journal of Clinical Investigation·Ali Abbara, Waljit S Dhillo
Nov 13, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hwal Rim JeongIl Tae Hwang
Mar 7, 2021·International Journal of Molecular Sciences·Luigi NapolitanoMassimiliano Creta

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