Serum mannose-binding lectin levels after aneurysmal subarachnoid hemorrhage

Acta Neurologica Scandinavica
J-Y CaiZ-Q Yu

Abstract

Mannose-binding lectin (MBL) is a key molecule of complement system, which is activated after aneurysmal subarachnoid hemorrhage (aSAH). We investigated the association of serum MBL levels with injury severity and clinical outcomes among aSAH patients. Serum MBL levels were determined in 132 aSAH patients and 132 controls. We assessed the association of serum MBL levels with 6-month mortality and unfavorable outcome (Glasgow Outcome Scale score, 1-3) and injury severity reflected by World Federation of Neurological Surgeons (WFNS) scores and modified Fisher scores. Factors found significant on univariate analysis were further tested on a multivariate model. Meantime, the prognostic predictive values were evaluated using a receiver operating curves analysis. Serum MBL levels were significantly higher in patients than in controls. Serum MBL levels were independently associated with WFNS scores and modified Fisher scores. MBL was identified as an independent prognostic predictor for 6-month mortality and unfavorable outcome. Moreover, its predictive value was similar to those of WFNS scores and modified Fisher scores. Elevated serum MBL concentrations are associated with injury severity and long-term poor prognosis after aSAH.

References

Feb 24, 2000·Acta Neurologica Scandinavica·P J JongenK J Lamers
May 26, 2004·Molecular Immunology·Mihaela GadjevaSteffen Thiel
Jun 16, 2004·Clinical and Experimental Immunology·E D PedersenT E Mollnes
Jul 11, 2006·Neurosurgery·J MoccoE Sander Connolly
Feb 9, 2007·Journal of Human Hypertension·S K Nadar, G Y H Lip
Jul 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Damon P EisenEmma S McBryde
Nov 22, 2008·Biochemical Society Transactions·Peter Garred
Apr 11, 2009·Stroke; a Journal of Cerebral Circulation·Jennifer A FronteraStephan A Mayer
Oct 3, 2009·Annals of Neurology·Raffaella GesueteMaria-Grazia De Simoni
Jan 7, 2011·Current Neurovascular Research·Helena MorrisonLeslie Ritter
Dec 1, 2011·Critical Care : the Official Journal of the Critical Care Forum·Xiang-Dong ZhuJian-Min Zhang
Jul 20, 2012·The Pediatric Infectious Disease Journal·Joël IsraëlsTaco W Kuijpers
Jul 25, 2013·Critical Care : the Official Journal of the Critical Care Forum·Jian-Wei PanRen-Ya Zhan
Dec 7, 2013·Neurochemical Research·Zhen-Yu WangLi-Ming Zhang
Mar 29, 2014·Stroke; a Journal of Cerebral Circulation·Xavier de la RosaAnna M Planas
May 7, 2014·Sub-cellular Biochemistry·Masaru Nonaka
Mar 19, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Manuela ScorzaGiuseppe Castaldo
Apr 14, 2015·Acta Neurologica Scandinavica·C LindgrenS Naredi
Jun 16, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Jun 18, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Aug 25, 2015·Korean journal of pediatrics·Heeyeon Cho

❮ Previous
Next ❯

Citations

Dec 8, 2019·Translational Stroke Research·Bart J van DijkMervyn D I Vergouwen
Apr 21, 2018·Molecular Neurobiology·E SandgaardAnne-Mette Hvas
Nov 14, 2020·Journal of Neuroinflammation·Jeppe Sillesen MatzenSøren Bache

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.