Serum markers and intestinal mucosal injury in chronic gastrointestinal ischemia.

Digestive Diseases and Sciences
Désirée van NoordErnst J Kuipers

Abstract

Diagnosing chronic gastrointestinal ischemia (CGI) is a challenging problem in clinical practice. Serum markers for CGI would be of great diagnostic value as a non-invasive test method. This study investigated serum markers in patients with well-defined ischemia. Furthermore, intestinal mucosal injury was also evaluated in CGI patients. Consecutive patients suspected of CGI were prospectively enrolled and underwent a diagnostic work-up consisting of gastrointestinal tonometry and either CT or MR angiography. Blood samples for analysis of intestinal fatty acid-binding protein (I-FABP), D-dimer, lactate dehydrogenase (LDH), leucocyte counts, C-reactive protein (CRP), and L-lactate were drawn before and after a standard meal. Intestinal mucosal injury was assessed with glutamine, citrulline and arginine in blood samples and compared to a sugar absorption test (SAT). Test reproducibility was validated in healthy subjects. Forty patients and nine healthy subjects were included. Ischemia was diagnosed in 32 patients (80%). I-FABP, leucocyte counts, LDH, CRP, glutamine, citrulline, arginine and SAT levels did not differ between patients with and without ischemia. L-lactate concentration showed a significant elevation in ischemia patie...Continue Reading

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Citations

Oct 10, 2014·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M ReichertA Hecker
Mar 13, 2014·World Journal of Gastroenterology : WJG·Thijs R van OudheusdenMisha Dp Luyer
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Mar 19, 2020·Current Gastroenterology Reports·Karthik Gnanapandithan, Paul Feuerstadt

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Methods Mentioned

BETA
enzyme-linked
ELISA
flowcytometric
blood sample collections

Software Mentioned

SPSS

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