PMID: 3752065Oct 1, 1986Paper

Serum markers for type IV collagen and type III procollagen in the myelofibrosis-osteomyelosclerosis syndrome and other chronic myeloproliferative disorders

American Journal of Hematology
H HasselbalchJ Risteli

Abstract

Myelofibrosis is characterized by excessive deposition of interstitial and basement membrane collagens in the bone marrow. In this study, specific radioimmunoassays for the aminoterminal propeptide of type III procollagen and for the 7S collagen domain of type IV (basement membrane) collagen were used to determine how this accumulation is reflected in serum. Of the 41 patients with chronic myeloproliferative disorders studied, the highest levels of both parameters were found in idiopathic myelofibrosis and in chronic myelogenous leukaemia associated with bone marrow fibrosis. Increasing degrees of bone marrow fibrosis were accompanied by increasing serum concentrations of both markers, except for osteomyelosclerosis, where notably low values were seen. Pathologically high values of one or both parameters were also found in a few patients with polycythaemia vera or a transitional myeloproliferative disorder. The antigens related to type III procollagen and type IV collagen correlated significantly with each other and with the leucocyte count. These parameters should provide noninvasive means for following the accumulation of interstitial and basement membrane collagens in the bone marrow.

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Citations

Jan 1, 1993·International Journal of Clinical & Laboratory Research·H C Hasselbalch
Feb 14, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·T InuiY Kajita
Sep 1, 1994·British Journal of Haematology·J T Reilly
Jan 1, 1989·Acta Pathologica Japonica·E MatsumotoA Ooshima
Feb 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·I LisseP Junker
Jun 1, 1992·Journal of Clinical Pathology·J T Reilly
Jan 1, 1994·International Archives of Occupational and Environmental Health·T H JornaE F Wouters
Oct 4, 2007·British Journal of Haematology·David J KuterRobert P Hasserjian
Aug 1, 1994·Leukemia Research·H Hasselbalch, P Junker
Jun 20, 2003·Respiratory Medicine·C NordenbaekP Junker
Sep 1, 1989·The British Journal of Dermatology·P D MauriceP M Dowd
Jul 1, 1986·British Journal of Haematology·M Apaja-SarkkinenL Risteli
Nov 1, 1990·European Journal of Haematology·Y NajeanJ P Arrago
Jun 4, 2015·Expert Review of Hematology·Sarah FarmerHenrik Frederiksen
May 1, 1991·European Journal of Haematology·H Hasselbalch, I Lisse
Aug 1, 1990·European Journal of Haematology·H Hasselbalch
Jan 1, 1991·American Journal of Hematology·H HasselbalchA Engström Laurent
Mar 1, 1995·Clinical and Laboratory Haematology·J T ReillyA Smith

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