Serum Markers in Rheumatoid Arthritis: A Longitudinal Study of Patients Undergoing Infliximab Treatment

International Journal of Rheumatology
Oddgeir SelaasKarl A Brokstad

Abstract

Objective. The aim of this study was to investigate the clinical effect and serum markers in a cohort of rheumatoid arthritis patients with moderate to high disease activity, participating in an open clinical phase IV study conducted in Norway between 2001 and 2003 receiving infliximab treatment. Method. A total of 39 patients were studied, with a mean age of 54 years and 12-year disease duration. The analyses were performed using serum from patients at four assessment time points: baseline and 3, 6, and 12 months after starting treatment with infliximab. A wide variety of clinical data was collected and disease activity of 28 joints and Simple Disease Activity Index were calculated. The joint erosion was determined by X-ray imaging and the Sharp/van der Heijde score was determined. Serum analysis included multiplex immunoassays for 12 cytokines, 5 matrix metalloproteases, and 2 VEGFs. Results. The majority of the RA patients in this study had initially moderate to high disease activity and the infliximab treatment reduced the disease activity significantly and also reduced any further joint destruction and improved disease status. Most of the serum levels of cytokines and metalloproteases remained unchanged during the course o...Continue Reading

References

Feb 24, 2007·Nature Reviews. Molecular Cell Biology·Andrea Page-McCawZena Werb
Sep 29, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Anne Grimstvedt KvalvikJohan Gorgas Brun
Dec 1, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Akihiko BanYoshiki Nishizawa
Jul 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc Feldmann, Ravinder N Maini
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Feb 19, 2013·Immunotherapy·Giuseppe MurdacaFrancesco Puppo
Mar 28, 2013·Mediators of Inflammation·Giulio KleinerGiorgio Zauli

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Citations

Jun 25, 2016·Circulation Research·Sarah A Dick, Slava Epelman
Aug 2, 2017·Journal of Cardiovascular Pharmacology·Maradumane L MohanSathyamangla V Naga Prasad
Aug 6, 2017·Current Cardiology Reports·Luigi M BiasucciGiovanna Liuzzo

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Methods Mentioned

BETA
ESR
X-ray

Software Mentioned

GraphPad
GraphPad Prism
STarStation

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