Serum markers of bone formation in parenteral nutrition patients

Calcified Tissue International
E W LipkinL J Deftos

Abstract

Bone gamma-carboxyglutamic acid containing protein (BGP) has been utilized effectively as a serum marker of bone turnover in healthy normals and in individuals with a variety of metabolic bone disorders including postmenopausal osteoporosis and Paget's disease. The utility of this serum marker in other bone disorders, including that associated with the maintenance of patients on long-term parenteral nutrition, still requires definition. Because of our interest in this clinical syndrome and the availability of serum and of bone formation rates (BFR) measured directly from double tetracycline labeling in 11 long-term parenteral nutrition patients, we measured BGP levels in these patients and attempted to correlate this measure with BFR. Serum vitamin D metabolites, immunoreactive parathyroid hormone (PTH), and alkaline phosphatase (alk phos) were also measured. Serum BGP was only weakly and not significantly correlated (r = 0.24, p = NS) with bone formation rate for the group as a whole. However, in a subgroup of 10 patients without hyperparathyroidism, there was strong and significant correlation (r = 0.81, P less than 0.01) between BGP and BFR. There was also a strong correlation between bone formation rate and serum 1,25 dihyd...Continue Reading

References

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Citations

Aug 1, 1991·Calcified Tissue International·A M Parfitt
Jul 3, 1998·Gastroenterology Clinics of North America·E W Lipkin
Jan 1, 1994·Critical Reviews in Clinical Laboratory Sciences·G L Klein, J W Coburn
Aug 1, 1996·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L PironiM Miglioli
Aug 23, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A L Buchman, A Moukarzel
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·E W Lipkin
Aug 27, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Charlène DerepasGlenda Courtney-Martin
Dec 30, 2009·Journal of Pediatric Gastroenterology and Nutrition·Timothy A SentongoAlan L Buchman

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