Serum Markers of Epithelial Mesenchymal Transition as Predictors of HCV-induced Liver Fibrosis, Cirrhosis and Hepatocellular Carcinoma

Electronic Physician
M ZoheiryInas Raafat

Abstract

Hepatitis C virus (HCV) is a major cause of chronic liver disease in Egypt, leading to hepatic fibrosis, liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Liver fibrosis is characterized by excessive deposition of extracellular matrix (ECM). Newly-recognized pathogenic mechanisms point to the epithelial-mesenchymal transition (EMT) of hepatocytes to matrix synthesizing (myo-) fibroblasts. Transforming growth factor-beta (TGF-β1), bone morphogenic protein (BMP)-7, and connective tissue growth factor (CTGF) are biomarkers reflecting the EMT process. YKL-40 is a glycoprotein member of ECM and plays a role in cancer cell proliferation. The purpose of this study was to determine the serum biomarkers of EMT and its impact on the fibrogenic process and tumorigenesis in HCV-genotype 4 patients. In this case-control study that was conducted in 2013-2014, 97 HCV-infected patients were subjected to clinical examination, laboratory investigations, and liver biopsy. According to the histopathologic examination, they were classified to F0 (14 cases), F1 (17 cases), F2 (15 cases), F3 (18 cases), F4 (22 cases), and HCC (11 cases). Fifteen age- and gender-matched subjects were included as normal controls. Serum levels of TGF-β1, BMP-7, ...Continue Reading

Citations

Sep 20, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Seyyed Mortaza HaghgooSeyed Moayed Alavian
Apr 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mary F BarbeSteven N Popoff

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
enzyme-linked
ELISA
enzyme-linked immunosorbent ELISA

Software Mentioned

Excel
Metavir
SPSS

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