Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

Neuromuscular Disorders : NMD
Cynthia P W SoonQiao-Xin Li

Abstract

Amyotrophic lateral sclerosis (ALS) is an adult-onset fatal neurodegenerative disorder characterized by progressive deterioration of motor neurons in the spinal cord, brainstem, and cerebral cortex. Matrix metalloproteinase-9 (MMP-9) is proposed to be a biomarker for ALS due to a potential pathological role in the disease. However, despite numerous studies, it is still unclear whether there is a direct correlation between MMP-9 expression in serum and progression of disease. Therefore, we used a TgSOD1(G93A) mouse with a low transgene copy number. This model shows slow disease progression analogous to human ALS and provides a useful model to study biomarker expression at different stages of disease. Using zymography, we found that serum MMP-9 activity was significantly elevated in animals showing early signs of disease when compared to the younger, pre-symptomatic animals. This was followed by a decrease in MMP-9 activity in TgSOD1(G93A) mice with end-stage disease. These results were confirmed in serum of a high copy number strain of TgSOD1(G93A) mice with rapid progression. MMP-9 expression was changed accordingly in spinal motor neurons, glia and neuropil, suggesting a spinal cord contribution to blood MMP-9 activity. Serum ...Continue Reading

References

Jan 1, 1993·Journal of Neuro-oncology·B W Ennis, L M Matrisian
Oct 17, 1998·Neuropathology and Applied Neurobiology·S KherifH S Alameddine
Jul 4, 2001·Nature Reviews. Neuroscience·V W YongD R Edwards
May 15, 2002·Brain Research. Molecular Brain Research·E M MuirJ H Rogers
Jun 22, 2002·Brain : a Journal of Neurology·Fiona M MenziesPamela J Shaw
Jun 26, 2004·Annual Review of Neuroscience·Lucie I BruijnDon W Cleveland
Aug 12, 2004·Free Radical Biology & Medicine·Kristin K Nelson, J Andres Melendez
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chetan VijayvergiyaGiovanni Manfredi
May 26, 2006·Expert Reviews in Molecular Medicine·Emily F Goodall, Karen E Morrison
Aug 23, 2006·Nature Reviews. Neuroscience·Piera Pasinelli, Robert H Brown
Oct 4, 2006·Neuron·Séverine BoilléeDon W Cleveland
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ke-Jie YinJin-Moo Lee
Feb 20, 2008·Progress in Neurobiology·Bradley J Turner, Kevin Talbot
May 10, 2008·Expert Review of Proteomics·Henrik Ryberg, Robert Bowser
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elisabetta MantuanoW Marie Campana

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Citations

Aug 27, 2014·BioMed Research International·Ana C CalvoRosario Osta
Jul 23, 2014·Journal of Neural Transmission·Marta Łukaszewicz-ZającAgnieszka Słowik
Sep 1, 2012·Translational Stroke Research·Maria Carolina O RodriguesSvitlana Garbuzova-Davis
Jul 4, 2012·Brain Research·Svitlana Garbuzova-DavisPaul R Sanberg
Feb 22, 2011·Journal of Neuroscience Research·Kazunori MiyazakiKoji Abe
Nov 6, 2015·Mediators of Inflammation·Marjana BrkicRoosmarijn E Vandenbroucke
Jun 3, 2011·Brain Research·Svitlana Garbuzova-DavisPaul R Sanberg
Aug 14, 2012·Neurobiology of Disease·Hala S Alameddine
Jun 7, 2014·Frontiers in Cellular Neuroscience·Dora Brites, Ana R Vaz
Dec 3, 2016·Journal of Neuromuscular Diseases·Hala S Alameddine, Jennifer E Morgan
Jun 15, 2019·Cellular and Molecular Life Sciences : CMLS·Santiago RiveraKévin Baranger
Mar 16, 2019·Frontiers in Aging Neuroscience·Emiliano TriasLuis Barbeito
Jul 15, 2021·The Journal of Physiology·Thomas WeddellChris Shaw

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