Serum matrix metalloproteinase-9 is elevated in men with a history of myocardial infarction

Scandinavian Journal of Clinical and Laboratory Investigation
J RenkoS T Nikkari

Abstract

Elevated serum inflammatory markers have been reported in coronary heart disease. Levels of serum matrix metalloproteinase-9 (MMP-9), C-reactive protein (CRP), C3-complement (C3) and autoantibodies against oxidized low-density lipoprotein (oxLDL) in 120 male subjects with a history of myocardial infarction (MI) were compared with those in 250 age-matched controls, both groups from a large cross-sectional population survey, the FINRISK study. The concentrations of serum MMP-9 and autoantibodies against oxLDL were measured by enzyme-linked immunosorbent assay, CRP and C3 by immunonephelometry. MMP-9, CRP and C3 concentrations were higher in the subjects with a history of MI than in the controls (p=0.037, p=0.004, and p=0.006, respectively). There was no difference between the groups in serum levels of autoantibodies against oxLDL. In other background characteristics, men in the MI group had higher body mass index (BMI) and serum triglyceride values and lower serum HDL cholesterol values compared to controls (p=0.009, p=0.001, and p<0.001, respectively). When analyzed by stepwise multiple logistic regression using BMI, HDL cholesterol, triglycerides, CRP, C3 and MMP-9 as independent variables, the significant predictors for MI wer...Continue Reading

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Citations

Nov 29, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Kathryn M ThrailkillRobert C Bunn
Feb 9, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·A KalelaS T Nikkari
Dec 19, 2013·The Journal of International Medical Research·Mingjiang LiCongxin Huang
Oct 28, 2019·International Journal of Environmental Research and Public Health·Grzegorz Józef NowickiEwa Rudnicka-Drożak
Sep 1, 2006·Journal of Clinical Neurology·Hahn Young Kim, Seol-Heui Han
Nov 15, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·J HernesniemiP J Karhunen
Jul 1, 2014·Basic & Clinical Pharmacology & Toxicology·Aline AzevedoRaquel F Gerlach
Jan 25, 2008·Bulletin of Experimental Biology and Medicine·G T SukhikhV N Serov
Mar 17, 2010·Progress in Cardiovascular Diseases·Magnus BäckStefan Agewall

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