Serum medroxyprogesterone acetate (MPA) concentrations and ovarian function following intramuscular injection of depo-MPA

The Journal of Clinical Endocrinology and Metabolism
A OrtizD R Mishell


A sensitive radioimmunoassay measuring serum medroxyprogesterone acetate (MPA) has been developed in order to measure and correlate serum MPA concentrations and ovarian function in women following im administration of deop-MPA (DMPA), employing goat anti-MPA-3-(O-carboxymethyl) oxime-bovine serum albumin and MPA-3-(O-carboxymethyl) imino-125I-iodohistamine. In the 3 women studied, im injection of 150 mg of DMPA yielded brief initial serum MPA concentrations ranging from 1.5 to 3 ng/ml for a few days. Serum MPA concentrations gradually declined and remained relatively constant at about 1 ng/ml for 2 to 3 months, declined gradually thereafter reaching 0.2 ng/ml during the 6th month and became undetectable (less than 0.02 ng/ml) about 7-1/2 to 9 months following administration. Serum estradiol remained at early to midfollicular phase levels for 4 to 6 months after DMPA injection and rose to preovulatory levels when serum MPA levels fell below 0.5 to 0.25 ng/ml. Ovulation, however, as evidenced by serum progesterone concentrations did not occur, apparently due to suppression of the LH peak by positive feedback inhibition. Prolonged inhibition of cyclic ovarian function following DMPA injection is caused by slow MPA absorption and p...Continue Reading


Apr 29, 2006·European Journal of Clinical Pharmacology·Jiang-Wei ZhangLing Yang
Aug 8, 2013·Journal of Bone and Mineral Metabolism·Opeyemi O Babatunde, Jacky J Forsyth
Jun 1, 1995·Contraception·C WesthoffL Tiezzi
Apr 1, 1978·Journal of Steroid Biochemistry·K ShrimankerK Fotherby
Jul 1, 1979·Journal of Steroid Biochemistry·K Fotherby
Aug 1, 1981·Journal of Steroid Biochemistry·M Mathrubutham, K Fotherby
Jul 1, 1997·Contraception·S TaneepanichskulK Chaturachinda
Feb 5, 1999·Obstetrics and Gynecology·D ScholesW E Barlow
Sep 24, 1999·Pediatric Clinics of North America·Zeev Harel, B Cromer
Sep 4, 1999·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·P J Flanagan, Zeev Harel
Feb 24, 2001·Clinical Obstetrics and Gynecology·A M Kaunitz
Aug 2, 2008·Obstetrics and Gynecology·Belinda J YaugerPamela Stratton
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Karen PazolKim Wallen
Mar 31, 2004·Journal of Pediatric and Adolescent Gynecology·Andrea E BonnyGail B Slap
May 15, 2008·Contraception·Markus J SteinerCharles Morrison
Apr 1, 1986·Journal of Obstetrics and Gynaecology·K Fotherby, G Howard
Jan 1, 1989·Acta Oncologica·S LundgrenE Utaaker
Dec 7, 2007·Contraception·Lynn RosenbergMargaret Hoffman
May 3, 2007·Obstetrics and Gynecology Clinics of North America·Stephanie B Teal, David M Ginosar
Dec 19, 2006·Journal of Pediatric and Adolescent Gynecology·Zeev Harel
Jun 25, 2008·Annals of the New York Academy of Sciences·Zeev Harel
Apr 1, 1978·Contraception·K FotherbyB N Saxena
Dec 1, 1986·Clinical Endocrinology·P PetsosD C Anderson
Jun 23, 2005·Journal of Pediatric and Adolescent Gynecology·Zeev Harel
Nov 25, 2000·Obstetrics and Gynecology Clinics of North America·A M Kaunitz
May 17, 2002·American Journal of Obstetrics and Gynecology·Tim CundyI R Reid
Oct 30, 2016·Journal of Pediatric and Adolescent Gynecology·Hannah L H LangeAndrea E Bonny
Nov 1, 1980·Contraception·K FotherbyM Mathrubutham
Jun 1, 1990·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·B M Landgren
Jul 6, 1991·BMJ : British Medical Journal·T CundyI R Reid
Nov 9, 2005·The Journal of Family Planning and Reproductive Health Care·Ruth Holman, Gillian Stephen
Jun 1, 2005·The Journal of Family Planning and Reproductive Health Care·Faculty of Family Planning and Reproductive Health Care Clinical Effectiveness Unit
Aug 18, 2005·The Journal of Family Planning and Reproductive Health Care·Gillian PenneyClinical Effectiveness Unit (CEU) of the Faculty of Family Planning and Reproductive Health Care (FFPRHC), Royal College of
Mar 1, 2019·Journal of the International AIDS Society·Flavia Matovu KiweewaMTN-020/ASPIRE Study Team
Dec 1, 1987·British Journal of Obstetrics and Gynaecology·B BazinJ Paris
Oct 1, 1989·British Journal of Obstetrics and Gynaecology·P W ReginaldR W Beard
Jan 9, 2018·Endocrine Reviews·Janet P HapgoodZdenek Hel
Oct 15, 2014·Clinical Obstetrics and Gynecology·Pamela A Royer, Kirtly P Jones
Sep 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rodolfo D Vicetti MiguelThomas L Cherpes
Jun 17, 1997·Annals of the New York Academy of Sciences·J S Sanfilippo
Apr 19, 2019·AIDS Research and Human Retroviruses·Andrea Ries ThurmanGustavo F Doncel
Sep 1, 1994·Asia-Oceania Journal of Obstetrics and Gynaecology·P VirutamasenC Gua
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rosie MngqibisaA5338 Study Team
Apr 12, 2017·AIDS Research and Human Retroviruses·Andrea Ries ThurmanGustavo F Doncel
Jun 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·K MavroudisD C Anderson
Nov 15, 2002·Paediatric Drugs·Zeev Harel
Jul 28, 2020·Domestic Animal Endocrinology·G M BragançaF Z Brandão

Related Concepts

Controlled-Release Preparations
Estradiol, (16 alpha,17 beta)-Isomer
Intramuscular Injection
Adgyn Medro
Progesterone, (9 beta,10 alpha)-Isomer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.