Serum melatonin levels are associated with mortality in patients with malignant middle cerebral artery infarction

The Journal of International Medical Research
Leonardo LorenteVictor García-Marín

Abstract

Objectives Lower serum melatonin levels are found in patients with ischaemic stroke compared with healthy controls. This study aimed to determine whether serum melatonin levels are associated with peroxidation status, antioxidant status, and mortality in patients with ischaemic stroke. Methods Patients with severe malignant middle cerebral artery infarction (MMCAI), defined as a Glasgow coma scale (GCS) score lower than 9, were included. Serum levels of melatonin, malondialdehyde (to assess lipid peroxidation), and total antioxidant capacity at the time of diagnosing MMCAI were determined. We chose 30-day mortality as the endpoint of the study. Results We found significantly higher serum levels of melatonin, total antioxidant capacity, and malondialdehyde in non-survivors (n = 32) than in survivors (n = 32) with MMCAI. Serum melatonin levels were associated with 30-day mortality (odds ratio = 2.205; 95% confidence interval = 1.294-3.759) after controlling for GCS score and age. We found a positive association between serum melatonin levels and total antioxidant capacity (rho = 0.36), and between serum melatonin and malondialdehyde levels (rho = 0.35). Conclusions Our study shows that serum melatonin levels are associated with p...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jul 13, 1974·Lancet·G Teasdale, B Jennett
Jun 1, 1993·Annals of Emergency Medicine·E D Hall
Aug 14, 1999·Scandinavian Journal of Immunology·P FiorinaP Dall'Aglio
Nov 9, 2000·Journal of Pineal Research·S CuzzocreaA P Caputi
Dec 21, 2000·Free Radical Biology & Medicine·A GhiselliC Scaccini
Mar 17, 2001·Journal of Clinical Pathology·I S Young, J V Woodside
Jul 11, 2003·Annals of the New York Academy of Sciences·Russell J ReiterDun Xian Tan
Aug 10, 2004·The Journal of Experimental Biology·David S WarnerInes Batinić-Haberle
Jan 13, 2006·British Journal of Pharmacology·Sian-Marie LucasRosemary M Gibson
Feb 18, 2006·Clinical Chemistry·Isabella Dalle-DonneAldo Milzani
Dec 6, 2008·The Journal of Veterinary Medical Science·Phil-Ok Koh
Mar 26, 2009·Journal of Pineal Research·Thomas RitzenthalerBruno Claustrat
Mar 2, 2011·Current Neuropharmacology·Emanuela Esposito, Salvatore Cuzzocrea
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·W BalduiniG Buonocore
May 21, 2013·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yuxin MaWanlong Lei
Jul 3, 2013·International Journal of Inflammation·Kate Marie LewisRobert Vink
Sep 17, 2014·Journal of Epidemiology·Kenji ObayashiNorio Kurumatani
Apr 25, 2016·Annals of Intensive Care·Leonardo LorenteAlejandro Jiménez

❮ Previous
Next ❯

Citations

Aug 1, 2020·Antioxidants·Nadia SadanandanCesar V Borlongan
Dec 15, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cheng-Peng ZhanGuo-Feng Yu
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui ZhangChangwei Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS
LogXact
NCSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.