Serum metabolite profiles as potential biochemical markers in young adults with community-acquired pneumonia cured by moxifloxacin therapy

Scientific Reports
Bo ZhouJianqing She

Abstract

Despite the utilization of various biochemical markers and probability calculation algorithms based on clinical studies of community-acquired pneumonia (CAP), more specific and practical biochemical markers remain to be found for improved diagnosis and prognosis. In this study, we aimed to detect the alteration of metabolite profiles, explore the correlation between serum metabolites and inflammatory markers, and seek potential biomarkers for young adults with CAP. 13 Eligible young mild CAP patients between the ages of 18 and 30 years old with CURB65 = 0 admitted to the respiratory medical department were enrolled, along with 36 healthy participants as control. Untargeted metabolomics profiling was performed and metabolites including alcohols, amino acids, carbohydrates, fatty acids, etc. were detected. A total of 227 serum metabolites were detected. L-Alanine, 2-Hydroxybutyric acid, Methylcysteine, L-Phenylalanine, Aminoadipic acid, L-Tryptophan, Rhamnose, Palmitoleic acid, Decanoylcarnitine, 2-Hydroxy-3-methylbutyric acid and Oxoglutaric acid were found to be significantly altered, which were enriched mainly in propanoate and tryptophan metabolism, as well as antibiotic-associated pathways. Aminoadipic acid was found to be s...Continue Reading

References

May 12, 2009·Nucleic Acids Research·Jianguo XiaDavid S Wishart
Aug 15, 2009·Journal of Proteome Research·Yunping QiuWei Jia
Dec 2, 2009·Nucleic Acids Research·Alex FrolkisDavid S Wishart
Jul 16, 2010·Bioinformatics·Jianguo Xia, David S Wishart
Jun 3, 2011·Current Protocols in Bioinformatics·Jianguo Xia, David S Wishart
May 4, 2012·Nucleic Acids Research·Jianguo XiaDavid S Wishart
Apr 2, 2013·Metabolomics : Official Journal of the Metabolomic Society·Jianguo XiaDavid S Wishart
May 16, 2013·Intensive Care Medicine·Christopher W SeymourDerek C Angus
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jiang-Han WangSai-Juan Chen
Nov 10, 2013·Nucleic Acids Research·Timothy JewisonDavid S Wishart
Apr 22, 2015·Nucleic Acids Research·Jianguo XiaDavid S Wishart
Aug 19, 2015·Lancet·Elena PrinaAntoni Torres
Jun 10, 2016·Intensive Care Medicine·Catia CillónizFrancesco Blasi
Sep 8, 2016·Current Protocols in Bioinformatics·Jianguo Xia, David S Wishart
Jan 10, 2017·Current Opinion in Infectious Diseases·Davide Leoni, Jordi Rello
Feb 2, 2019·Intensive Care Medicine·Antoni TorresRichard G Wunderink
Apr 28, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Nobuhiro AsaiHiroshige Mikamo
May 8, 2019·PloS One·Daniel C MüllerAnders Johansson

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Citations

Jun 28, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Sergio SalgüeroUNKNOWN Escorial Study Group
Mar 5, 2021·Metabolism: Clinical and Experimental·Ding ShiLanjuan Li

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Methods Mentioned

BETA
metabolomics profiling
PCR

Software Mentioned

SPSS
XploreMET
MetaboAnalyst
PLS
DA

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