Serum metabolomic profile as a means to distinguish stage of colorectal cancer.

Genome Medicine
Farshad FarshidfarOliver F Bathe

Abstract

Presently, colorectal cancer (CRC) is staged preoperatively by radiographic tests, and postoperatively by pathological evaluation of available surgical specimens. However, present staging methods do not accurately identify occult metastases. This has a direct effect on clinical management. Early identification of metastases isolated to the liver may enable surgical resection, whereas more disseminated disease may be best treated with palliative chemotherapy. Sera from 103 patients with colorectal adenocarcinoma treated at the same tertiary cancer center were analyzed by proton nuclear magnetic resonance (1H NMR) spectroscopy and gas chromatography-mass spectroscopy (GC-MS). Metabolic profiling was done using both supervised pattern recognition and orthogonal partial least squares-discriminant analysis (O-PLS-DA) of the most significant metabolites, which enables comparison of the whole sample spectrum between groups. The metabolomic profiles generated from each platform were compared between the following groups: locoregional CRC (N = 42); liver-only metastases (N = 45); and extrahepatic metastases (N = 25). The serum metabolomic profile associated with locoregional CRC was distinct from that associated with liver-only metastas...Continue Reading

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
1
H
metabolomic profiling
nuclear
PCA

Software Mentioned

SIMCA
Ingenuity Pathways Analysis ( IPA )
Metabolite Detector
O2
Metz
Umetrics
Chenomx NMR Suite
IPA
ROC
Chenomx

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