Serum metabolomics research of the anti-hypertensive effects of Tengfu Jiangya tablet on spontaneously hypertensive rats

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Haiqiang JiangChuanhua Yang

Abstract

A HPLC/TOF-MS-based metabolomic study was conducted to investigate the holistic therapeutic effects of Tengfu Jiangya Tablet (TJT) on spontaneously hypertensive rats (SHRs). The SHRs were divided into valsartan (VST) group, TJT group and model group, in addition, the Wistar-Kyoto rats (WKY) were taken as normal control. Serum samples were separated and identified by HPLC/TOF-MS, while the obtained data was further processed by partial least-squares discriminant analysis (PLS-DA). A clear cluster among the four groups was observed, and we identified thirteen biomarkers involved involved in sphingolipid metabolism (sphinganine, lysosphingomyelin, ceramide), glycerophospholipid metabolism (phosphatidylcholines, phosphatidylethanolamine, lysophosphatidylcholines), arginine and proline metabolism (l-proline, citrulline), tryptophan metabolism (xanthuiulrenic acid, l-kynurenine, l-tryptophan), arachidonic acid metabolism(leukotriene D4), and linoleic acid metabolism (gamma-linolenic acid). Altered metabolic pathways involved in impaired NO production, inflammation and vascular smooth muscle cells (VSMCs) apoptosis and proliferation, which suggesting the possible pathological state in SHRs. TJT as well as VST altered the metabolic sta...Continue Reading

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Citations

Dec 30, 2017·Experimental and Therapeutic Medicine·Jiajing ZhaoYingjue Wang
Apr 15, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jingwen XuHaiqing Lin
Dec 14, 2018·Cellular and Molecular Life Sciences : CMLS·Ruth R MagayeBing H Wang
Jan 27, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Yueting DengChaofu Ke
Dec 31, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jiayun WuLi Huang

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