Abstract
Parkinson's disease (PD) is the result of progressive degeneration of the nigrostriatal dopaminergic pathway and depletion of neurotransmitter dopamine in the striatum. We included 17 patients with PD along with 7 patients of progressive supranuclear palsy (PSP), 6 patients of multiple system atrophy (MSA) and 22 age and sex-matched healthy controls. We analyzed metabolite profiles in the serum of these patients and controls using 1H NMR spectroscopy. Isoleucine, valine, alanine, glutamine and histidine in PD, PSP and MSA were significantly (P < 0.001) higher than controls, whereas, glutamate and glucose were significantly increased in PD (P < 0.001), PSP and MSA (P < 0.05) vs. Citrate was increased in PD, PSP and MSA (P < 0.05) vs. While, acetone, lactate and formate were higher at P < 0.001, threonine is increased at P < 0.05. The 3D scattered score plot of OPLS-DA model revealed clear differentiation among the groups, R2 = 0.92 and Q2 = 0.78. Significant differences in various metabolite levels were found between control and disease groups. Common amino acids that are significantly higher in all groups include branched chain amino acids, which could increase neuronal excitability.
Citations
Feb 18, 2020·Journal of Neural Transmission·Micaela Johanna GlatDaniel Offen
Oct 30, 2018·PloS One·Lucy StilesPaul F Smith
Mar 8, 2020·Nature Communications·Ji CaoMeidan Ying
Apr 24, 2020·Nature Reviews. Neurology·Nicholas J AshtonDag Aarsland
Aug 17, 2018·International Journal of Medicinal Chemistry·Mam Y MbogeSusan C Frost
May 3, 2019·Cancer & Metabolism·Matthias PietzkeUNKNOWN METTEN study group
Jan 13, 2019·Molecular Neurodegeneration·Yaping Shao, Weidong Le
Dec 20, 2018·The Analyst·Consuelo PizarroJosé-María González-Sáiz
Jan 24, 2019·International Journal of Molecular Sciences·Abdellah TebaniSoumeya Bekri
Jan 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sadhana KumariN R Jagannathan
Aug 11, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F J Jiménez-JiménezJ A G Agúndez
Oct 15, 2020·International Journal of Molecular Sciences·Jing XuRebecca C Ahrens-Nicklas
Jun 5, 2019·Analytical Biochemistry·Shiro KatoTadao Oikawa
May 29, 2021·Stem Cell Reports·Justyna OkarmusMorten Meyer
Jul 7, 2021·Expert Review of Proteomics·Nimisha GuptaSaima Wajid
Aug 4, 2021·Metabolic Brain Disease·Manjeet GuptaG Nagesh Babu
Aug 5, 2021·Experimental and Therapeutic Medicine·Adela Magdalena CiobanuMagdalena Budisteanu