Serum Methylarginines and Hearing Loss in a Population-based Cohort of Older Adults

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Mark A McEvoyJulia Z Sarant

Abstract

Age-related hearing loss is associated with endothelial dysfunction and increased cardiovascular risk, suggesting a vascular etiology. Methylarginines are endogenous nitric oxide synthase inhibitors that cause endothelial dysfunction and increase cardiovascular disease risk. This study is the first to examine the hypothesis that higher serum concentrations of methylarginines are associated with greater hearing loss prevalence. Cross-sectional audiometric data on hearing levels, and serum methylarginines were collected from a population-based sample of 630 older community-dwelling adults. Linear regression analysis showed a statistically significant association between higher serum concentrations of asymmetric dimethylarginine (ADMA) and L-arginine and greater degrees of hearing loss for males, particularly over 75 years. Higher body mass index and previous history of stroke were also associated with hearing loss. For females, ADMA concentration was not associated with hearing loss, but higher serum L-arginine concentrations were associated with reduced hearing loss prevalence in older females. Antihypertensive medication use was also associated with reduced hearing loss prevalence. LDL cholesterol and previous myocardial infarc...Continue Reading

References

Aug 1, 1994·Journal of the American College of Cardiology·D S CelermajerJ E Deanfield
Feb 1, 1993·Archives of Otolaryngology--head & Neck Surgery·G A GatesP A Wolf
Jan 1, 1996·The Laryngoscope·D G KaramitsosC M Koutsojannis
Nov 4, 1998·American Journal of Epidemiology·K J CruickshanksD M Nondahl
Mar 3, 1999·Audiology : Official Organ of the International Society of Audiology·H NaramuraA Yamamoto
Aug 19, 2000·Annals of Medicine·O T Raitakari, D S Celermajer
Feb 1, 2002·International Journal of Epidemiology·D SindhusakeG Rubin
Mar 13, 2003·Kidney International·Aaron ErdelyChris Baylis
Apr 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Patrick Vallance, James Leiper
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Dierk H Endemann, Ernesto L Schiffrin
Jan 10, 2006·Journal of the American Geriatrics Society·Elizabeth P HelznerAnne B Newman
Mar 6, 2007·The Laryngoscope·Pasquale CapaccioLorenzo Pignataro
Sep 14, 2007·Acta Oto-laryngologica·Masaaki TeranishiTsutomu Nakashima
Jan 18, 2008·Journal of the American Society of Nephrology : JASN·Mahmut Ilker YilmazJonas Axelsson
Feb 23, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Tora LeongUNKNOWN Swedish-Irish-Norwegian Collaboration
Apr 3, 2008·Annals of Medicine·Thomas MünzelEberhard Schulz
Jun 28, 2008·Stroke; a Journal of Cerebral Circulation·Herng-Ching LinHsin-Chien Lee
Dec 19, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yuri AgrawalJohn K Niparko
Apr 1, 2009·Expert Opinion on Drug Metabolism & Toxicology·Carol Wadham, Arduino A Mangoni
Apr 25, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Jill Melendez YoungVandana Menon
Oct 7, 2009·Advances in Clinical Chemistry·Arduino A Mangoni
Sep 1, 2005·Women's Health·Ra Anderson, Mj Walton
Nov 10, 2009·Journal of Aging and Health·Anthony HoganHal Kendig
Jan 9, 2010·International Journal of Epidemiology·Mark McEvoyJohn Attia
Feb 26, 2010·Journal of Alzheimer's Disease : JAD·Chengxuan QiuLaura Fratiglioni
Jun 12, 2010·American Journal of Audiology·Raymond H Hull, Stacy R Kerschen
Apr 19, 2011·Current Hypertension Reports·Agostino VirdisStefano Taddei
Jun 9, 2011·Journal of the American Geriatrics Society·Elizabeth P HelznerAnne B Newman
Jun 18, 2011·American Journal of Public Health·Mary E FischerTed S Tweed
Jul 20, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Frank R Lin
Feb 15, 2012·Archives of Internal Medicine·Wade Chien, Frank R Lin
Mar 1, 2012·Archives of Internal Medicine·Frank R Lin, Luigi Ferrucci
Mar 31, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Ben Caplin, James Leiper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.