Serum microRNA-205 as a novel biomarker for cervical cancer patients

Cancer Cell International
Quanhui MaXiaoming Yao

Abstract

Serum microRNAs (miRNAs) are a novel class of diagnostic and prognostic biomarkers for numerous cancers. However, the level and clinical relevance of circulating miR-205 transcripts in human serum of cervical cancer patients are unclear. The purpose of this study was to determine serum miR-205 levels in cervical cancer patients and explore its association with clinicopathological factors and prognosis. Serum miR-205 expression was investigated in 60 cervical cancer patients and 60 healthy normal controls by using real-time PCR. Correlations between miR-205 expression and the clinicopathological features and prognosis of cervical cancer patients were then evaluated. Receiver operating characteristic curves were used to evaluate the sensitivity and specificity of serum miR-205. Serum miR-205 was significantly upregulated in cervical cancer patients compared with healthy donors (p < 0.01), and a high level of miR-205 expression was correlated with poor tumor differentiation (p = 0.009), lymph node metastasis (p = 0.015) and increased tumor stage (p = 0.001). The serum miR-205 level was capable of separating advanced stage from early stage metastatic cervical cancer from non-metastatic samples and poorly differentiated tumors from ...Continue Reading

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Citations

Mar 18, 2017·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Zhang YueXue Feng-Xia
Jan 30, 2018·Laboratory Medicine·Vishuda LaengsriPornlada Nuchnoi
Feb 6, 2019·Environmental Science and Pollution Research International·Bruno Ivo PelizaroRodrigo Juliano Oliveira
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Apr 23, 2020·Cancer Biotherapy & Radiopharmaceuticals·Hao LuoShouheng Wu
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Apr 4, 2021·Cancers·Shailendra Kumar Dhar DwivediResham Bhattacharya

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS

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