Serum microRNA-210 levels in different groups of chronic hepatitis B patients

Clinica Chimica Acta; International Journal of Clinical Chemistry
Fujun YuJianjian Zheng

Abstract

It has been reported that hepatitis B virus (HBV) replication can be suppressed by microRNA-210 (miR-210). However, whether serum miR-210 levels can serve as disease parameters in patients with chronic hepatitis B (CHB) remains unclear. Serum miR-210 levels were quantified in 115 CHB patients and 20 healthy controls by real-time PCR. We found that serum miR-210 levels can discriminate the different groups of CHB patients from healthy control (P<0.05), as well as patients with HBe antigen positive from those with HBe antigen negative (P<0.05). Serum miR-210 levels correlated with HBV DNA and HBs antigen (r=0.525, P<0.001 and r=0.348, P<0.001). Notably, inactive carrier patients with high (>3500 IU/mL) or low (<3500 IU/mL) levels of HBs antigen were differentiated by serum miR-210 levels (P<0.05). Moreover, serum miR-210 levels correlated with liver inflammatory activity markers including alanine aminotransferase (ALT) and HAI score. However, there was no correlation of serum miR-210 levels with parameters of liver function including serum albumin, international normalized ratio and bilirubin, as well as the stages of liver fibrosis. Serum miR-210 can be used as an indicator of HBV replication and translation, and a potential mar...Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jul 13, 2005·Cell·Carlo M Croce, George A Calin
Aug 17, 2005·Seminars in Liver Disease·Brian J McMahon
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Jan 7, 2006·Journal of Proteome Research·Matthias P A EbertChristoph Röcken
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Oct 3, 2006·Developmental Cell·Wigard P Kloosterman, Ronald H A Plasterk
Feb 23, 2008·Toxicology·Josef OzerShelli Schomaker
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Sep 6, 2008·PloS One·Shlomit GiladAyelet Chajut
Oct 4, 2008·The New England Journal of Medicine·Jules L Dienstag
Dec 5, 2008·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bulent Degertekin, Anna S F Lok
Jan 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian YaoXianghuo He
Apr 3, 2010·Translational Oncology·Allen S HoAlbert C Koong
Aug 24, 2010·Antiviral Research·Guang-ling ZhangHua Tang
Feb 15, 2011·Nucleic Acids Research·Nicoletta PotenzaAniello Russo
Jun 15, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Xiangyi LiuXinxin Lu
Jun 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Johan M LorenzenThomas Thum
Jul 26, 2011·FEBS Letters·Aniello Russo, Nicoletta Potenza
Oct 12, 2011·Annals of Hematology·Cheng FangJian-Yong Li
Apr 29, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Fujun YuJianjian Zheng

❮ Previous
Next ❯

Citations

Sep 22, 2016·Expert Review of Molecular Diagnostics·Jörg EllingerDimo Dietrich
Jan 21, 2017·Journal of Viral Hepatitis·Fujun YuJianjian Zheng
Sep 27, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ghulam MusaddaqMuhammad Imran Arshad
May 31, 2019·Journal of Cellular and Molecular Medicine·Wei WangJianjian Zheng
Sep 16, 2017·BioMed Research International·Xianliang HouHongyan Diao
Dec 29, 2018·Molecular Medicine Reports·Feifei LiJianni Qi
Aug 28, 2021·International Journal of Molecular Sciences·Raimonda Kubiliute, Sonata Jarmalaite

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

© 2021 Meta ULC. All rights reserved