Serum microRNA-365 in combination with its target gene TTF-1 as a non-invasive prognostic marker for non-small cell lung cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yanyan LiuYouguang Zheng

Abstract

MicroRNA (miR)-365 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) cells by targeting thyroid transcription factor 1 (TTF-1). To investigate miR-365 and TTF-1 mRNA expression in serum of NSCLC and their associations with patients' prognosis. MiR-365 and TTF-1 mRNA expression in 100 NSCLCs and 100 healthy control sera were detected by quantitative real-time PCR (qRT-PCR). MiR-365 expression level was significantly lower in NSCLC serum samples than in healthy control serum samples (P<0.001), while TTF-1 mRNA expression level was significantly increased in NSCLC serum samples compared to healthy control serum samples (P<0.001). In addition, low miR-365 expression and high TTF-1 expression, alone or in combination, were all significantly associated with poor differentiation (P=0.008, 0.008 and 0.001, respectively), advanced TNM stage (P=0.001, 0.005 and <0.001 respectively) and positive lymph node metastasis (P=0.02, 0.02 and 0.01, respectively) of NSCLC patients. Notably, NSCLC patients with combined low miR-365 expression and high TTF-1 expression (miR-365-low/TTF-1-high) had shortest overall survival (P<0.001). Furthermore, multivariate analysis showed that miR-365 expression (P=0.01), TTF-1 expression (P=0...Continue Reading

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Citations

Sep 6, 2018·Molecular Carcinogenesis·Ze-Bin JiangHui-Ting Yan
Dec 5, 2018·Bioscience Reports·Zhanzhan LiLiangfang Shen
May 31, 2019·Cellular and Molecular Life Sciences : CMLS·Daniele BellaviaG Giavaresi
Mar 1, 2019·Cancers·Shang-Gin WuJin-Yuan Shih
Mar 23, 2018·Cancer Biomarkers : Section a of Disease Markers·Runhua FengZhenggang Zhu
Dec 1, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Shen ZhongJürgen Borlak
Mar 25, 2019·Biochemical and Biophysical Research Communications·Hang LiSaijun Fan

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