Serum microRNA in patients undergoing atrial fibrillation ablation

Scientific Reports
Marek KiliszekAndrzej Skrobowski

Abstract

MicroRNAs mediate posttranscriptional gene regulation. The aim of the study was to find a microRNA predictor of successful atrial fibrillation (AF) ablation. A total of 109 patients undergoing first-time AF ablation were included. Nineteen patients were selected to undergo serum microRNA sequencing (study group). The sequencing data were used to select several microRNAs that correlated with 12-month recurrences after AF ablation. Those microRNAs were validated by digital droplet PCR in samples from remaining 90 patients. All patients underwent pulmonary vein isolation (RF ablation, contact force catheter, electroanatomical system). The endpoint of the study was the 12-month AF recurrence rate; the overall recurrence rate was 42.5%. In total, levels of 34 miRNAs were significantly different in sera from patients with AF recurrence compared to patients without AF recurrence. Six microRNAs (miR-183-5p, miR-182-5p, miR-32-5p, miR-107, miR-574-3p, and miR-144-3p) were validated in the whole group. Data from the validation group did not confirm the observations from the study group, as no significant differences were found between miRNAs serum levels in patients with and without recurrences 12 months after AF ablation.

References

Feb 1, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammUNKNOWN Scene 2 Investigators
Nov 28, 2013·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones
Jan 22, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shirley TamJohn D McPherson
Feb 6, 2014·JAMA : the Journal of the American Medical Association·Nassir F MarroucheJohannes Brachmann
Sep 27, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·David D McManusJane E Freedman
Dec 10, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sam RiahiSoren Hjortshoj
Jan 1, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hui JiangYinglong Hou
Jan 10, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Thomas PhlipsMattias Duytschaever
Mar 7, 2018·International Journal of Cardiology·S RobinsonM Hortmann
Jul 22, 2019·Journal of cardiology·Sumra KomalLi-Rong Zhang

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Citations

Dec 19, 2020·Journal of Strength and Conditioning Research·Manuel Fernández-SanjurjoEduardo Iglesias-Gutiérrez
Aug 15, 2021·Drug Metabolism and Personalized Therapy·Eric RytkinDmitry A Sychev

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Methods Mentioned

BETA
PCR

Software Mentioned

QuantaSoft
EdgeR
bcl2fastq
R
QuantaSoft Analysis Pro
miRSearch

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