Serum microRNA Signature Is Capable of Early Diagnosis for Non-Small Cell Lung Cancer

International Journal of Biological Sciences
Xia YangGuoan Chen

Abstract

Despite decades of efforts, non-small-cell lung cancer (NSCLC) remains the leading cause of cancer mortality globally primarily due to the challenge in early detection of the cancer. Being an important player in cancer development, the dysregulated miRNAs have been shown promising values as non-invasive diagnostic and prognostic biomarkers for NSCLC. The aim of our study is to access the efficacy and reliability of a potential circulating miRNA panel in early diagnosis of NSCLC. We first selected eight candidate miRNAs, miR-146b, miR-205, miR-29c, miR-31, miR-30b, miR-337, miR-411, and miR-708, which have been shown frequently aberrant in primary NSCLC patients based on our previous studies and other reports. The serum level of each of these miRNAs was evaluated by quantitative real-time PCR (qRT-PCR) in training and testing sets. We found that 5 out of 8 miRNAs (miR-146b, miR-205, miR-29c, miR-30b, and miR-337) were significantly up-regulated in NSCLCs patients compared to healthy or cancer-free controls in both training and testing sets. Based on the logistic regression model, a 4-miRNAs set (miR-146b, miR-205, miR-29c and miR-30b) was picked out of the 5 miRNAs owing to its excellent diagnostic power for NSCLC patients in th...Continue Reading

Citations

May 11, 2020·Human Cell·Jingyao WangYongqing Lai
Sep 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lisha YingDan Su
Mar 3, 2020·Life Sciences·Md Mahmodul Hasan Sohel
Dec 1, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Shen ZhongJürgen Borlak
Mar 9, 2021·Frontiers in Oncology·Xueyang CuiYuan Yuan
May 6, 2021·Diagnostics·Martina FaraldiGiovanni Lombardi
Jul 11, 2021·Journal of Clinical Laboratory Analysis·Liang WeiPingping Gong
Jul 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beilei ZhangFu Wang
Nov 28, 2021·International Journal of Molecular Sciences·Sarah Sayed HassaneinAhmed Lotfy Abdel-Mawgood

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

Statistical Package for the Social Sciences
DAVID
GraphPad Prism8

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