Serum midkine as a biomarker for malignancy, prognosis, and chemosensitivity in head and neck squamous cell carcinoma

Cancer Medicine
Taku YamashitaAkihiro Shiotani

Abstract

Improved therapies for individuals with head and neck squamous cell carcinoma (HNSCC) may be developed by identification of appropriate biomarkers. The aim of this study was to evaluate the usefulness of serum midkine measurement as a biomarker for HNSCC. Pretreatment serum midkine concentrations were measured in 103 patients with HNSCC and 116 control individuals by enzyme-linked immunosorbent assay. Midkine expression in tumor tissues from 33 patients with HNSCC who underwent definitive surgical resection without preoperative treatment was examined by immunohistochemistry. The cut-off serum midkine concentrations for predicting the presence of head and neck malignancy and chemosensitivity to induction chemotherapy, as determined using receiver operating characteristic curves, were 482 and 626 pg/mL, respectively. Spearman bivariate correlations showed positive correlations between serum midkine levels and immunohistochemistry staining score (r = 0.612, P < 0.001). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of serum midkine concentration for detection of HNSCC were 57.3, 85.3, 77.6, 69.2, and 72.1%, respectively. However, for predicting the response to induction chemotherap...Continue Reading

References

Jun 13, 1991·The New England Journal of Medicine·UNKNOWN Department of Veterans Affairs Laryngeal Cancer Study GroupWilliam G Henderson
Jan 1, 1997·British Journal of Cancer·K KadomatsuT Muramatsu
Oct 20, 1998·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·M KrimmelN Schwenzer
Aug 23, 2000·British Journal of Cancer·S IkematsuT Muramatsu
Mar 3, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W SteinerM Kron
Nov 1, 2002·Cancer Control : Journal of the Moffitt Cancer Center·Jochen A WernerBurkard M Lippert
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hio Chung KangJae-Gahb Park
Mar 12, 2004·Cancer Letters·Kenji Kadomatsu, Takashi Muramatsu
Jun 11, 2004·Journal of Biomedical Optics·Kazuhiro GonoTakao Endo
Jul 14, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Manabu MutoShiegaki Yoshida
Nov 16, 2005·The Annals of Otology, Rhinology, and Laryngology·Philippe CéruseFrançois Disant
Oct 27, 2006·Cell Biochemistry and Function·Natsuyo AkuzawaTakao Shinozawa
Feb 20, 2007·The Annals of Otology, Rhinology, and Laryngology·Gregory S WeinsteinNeil G Hockstein
Dec 19, 2007·Archives of Otolaryngology--head & Neck Surgery·Michael L HinniWolfgang Steiner
Dec 19, 2007·Archives of Otolaryngology--head & Neck Surgery·Gregory S WeinsteinHarry Quon
Feb 16, 2008·BMC Medical Genomics·Zongbing YouJonathan Melamed
Aug 7, 2008·British Journal of Cancer·K OtaY Ando
Nov 20, 2008·Cancer Science·Shinya IkematsuKenji Kadomatsu
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Mar 6, 2010·World Journal of Gastroenterology : WJG·Shinya Kodashima, Mitsuhiro Fujishiro
May 4, 2010·The Annals of Otology, Rhinology, and Laryngology·Akihiro ShiotaniKoichiro Saito
Aug 13, 2011·Head & Neck·Taku YamashitaAkihiro Shiotani
Sep 16, 2011·American Journal of Clinical Pathology·Yi-Ju HungKuo-Jang Kao
Jun 26, 2012·Pathology International·Kazuma Sakamoto, Kenji Kadomatsu
Jul 4, 2012·The Laryngoscope·Gregory S WeinsteinF Christopher Holsinger
Dec 18, 2012·Cancer Research·Satoshi KishidaKenji Kadomatsu
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
May 31, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wen-Wei ZhuQing-Hai Ye
Jun 4, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Masayuki TomifujiAkihiro Shiotani
Aug 1, 2013·Cytokine·Malgorzata Krzystek-KorpackaAndrzej Gamian
Oct 30, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Tai-Jan ChiuHock-Liew Eng
Feb 26, 2014·Molecular Cancer Research : MCR·Tamina RawnaqCenap Güngör
Apr 4, 2014·Biological & Pharmaceutical Bulletin·Chuanying XuYan Yu

❮ Previous
Next ❯

Citations

Nov 15, 2017·Expert Review of Molecular Diagnostics·Lidia Maria Rebolho Batista ArantesAndré Lopes Carvalho
Feb 20, 2019·Esophagus : Official Journal of the Japan Esophageal Society·Fumiaki ShiratoriHideaki Shimada
Jul 17, 2020·Frontiers in Oncology·Heleen KoningsKristien J Ledeganck
Mar 30, 2019·Annals of Gastroenterological Surgery·Masaaki ItoHideaki Shimada
Jan 19, 2018·International Journal of Molecular Medicine·Yongliang LuYing Bao
Mar 30, 2021·Journal of Proteome Research·Chao-Jung ChenChiu-Ching Huang
Dec 7, 2017·The American Journal of the Medical Sciences·Yao LiChunfang Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
enzyme‐linked immunosorbent assay
surgical resection

Software Mentioned

Statcel
Excel
JMP
WorkOut

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.