Serum miR-155 as a potential biomarker of male fertility

Human Reproduction
Christos TsatsanisAleksander Giwercman

Abstract

Are serum levels of micro-RNAs miR-155 and miR-146a associated with male fertility, low-grade systemic inflammation (LGSI) and androgens? miR-155 was associated with male subfertility independent of LGSI or androgens while miR-146a was only weakly associated with subfertility and LGSI. Male subfertility has been associated with LGSI as well as with androgen deficiency. miR-155 and miR-146a are central regulators of inflammation and their level in cells and in the serum has been associated with several inflammatory conditions. In this case-control study, two independent groups of 60 subjects each (exploratory and confirmatory cohort) were randomly selected from an ongoing study on subfertile men (in total: hypogonadal; n = 40, eugonadal; n = 40 and control group n = 39) at a University Hospital Reproductive Medicine Centre. Individuals were matched for age. Total RNA was isolated from cell-free serum. As internal control a synthetic miRNA, UniSp6, was added to each sample prior to extraction. miRNA expression levels were measured by real-time RT-PCR and presented as fold difference (arbitrary units, U) from control. Sera from these individuals had been previously analyzed for hormone and cytokine levels. Serum levels of miR-155 ...Continue Reading

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Citations

May 29, 2016·Journal of Theoretical Biology·Nafiseh SedaghatAli Shojaie
Nov 12, 2019·The Journal of International Medical Research·Baojian ZhangQiming Liu
Feb 23, 2020·Molecular Human Reproduction·A Vashisht, G K Gahlay
Nov 6, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina DoxakiChristos Tsatsanis
Jul 1, 2017·Journal of Assisted Reproduction and Genetics·Dorota TrzybulskaChristos Tsatsanis
Sep 28, 2016·Environmental Science and Pollution Research International·Cecilia VecoliMaria Grazia Andreassi
Jan 14, 2021·Reproduction in Domestic Animals = Zuchthygiene·Wangsheng ZhaoJiangjiang Zhu
Apr 4, 2021·International Journal of Molecular Sciences·Madalina Gabriela BarbuDragos Valentin Predescu
Jul 16, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Pan GeDang-Xia Zhou

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